- An ethnic Samoan, his parents, Tiaina Sr. and Luisa, were born on the island of Aunuu in American Somoa.
- According to the autopsy report released by the San Diego County medical examiner, Seau was completely sober when he shot himself in the chest and his cause of death has been ruled as a suicide.
- Did not begin speaking English until he was 7.
- Drafted in 1990 by the San Diego Chargers in the 1st round (5th pick) out of USC.
- He and ex-wife Gina Seau have 3 children: daughter Sydney Seau (born on Friday, August 27th, 1993) and sons Jake Ryan (born on Wednesday, October 18th, 1995) and Hunter Tiaina (born on Monday, September 11th, 2000). Seau's first son Tyler Seau was born in June 1989 by Melissa Waldrop.
- A member of the Laurel Elementary School (Oceanside, California) Hall of Fame.
- (Thursday, January 10th, 2013) Following a post modem examination of his brain, his family announced that Seau suffered from chronic traumatic encephalopathy (CTE), a progressive degenerative disease caused by repeated head trauma.
- Inducted into the Polynesian Football Hall of Fame in 2014 (inaugural class).
- Has announced that the San Diego Chargers has released him so he can seek a free-agent deal. (14 March 2003)
- Named to the Pro Bowl 12 times.
- The 5th of 7 children.
- Surname pronounced say-OW.
- He and now-ex wife Gina posed for the 2000 Sports Illustrated swimsuit issue.
- His Seau's The Restaurant was named "Best Sports Bar" by the San Diego Restaurant Association.
- On Tuesday, April 16th, 2003, the Miami Dolphins acquired Seau from the San Diego Chargers in exchange for an undisclosed 2004 draft choice. (April 2003)
- "Retired", first time on Monday, August 14th, 2006. Said no team wanted or needed him. Then New England Patriots called said they needed him. Signed with the Patriots on Friday, August 18th, 2006. (August 2006)
- He was released by the Miami Dolphins, on Monday, March 6th, 2006. (2006)
- Inducted into the Pro Football Hall of Fame in 2015.
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