- Her son Billy was born with a heart condition that requires him to have at least three open heart surgeries in his life, one of which was done already hours after his birth, when the condition was discovered.
- Has 2 children with her husband Jimmy Kimmel - a daughter Jane Kimmel (b. July 10, 2014) and a son William John ''Billy'' Kimmel (b. April 21, 2017).
- (July 13, 2013) Married her boyfriend of 3 years Jimmy Kimmel following a 10-month-long engagement.
- Second wife of Jimmy Kimmel.
- Stepmother of Katie Kimmel and Kevin Kimmel.
- Has two siblings: older brother Michael McNearney, Jr. (born 1976) and younger sister Kelly McNearney (born 1981), who is the former Digital Account Executive at ESPN now Senior Account Executive with Google.
- Sister-in-law of Jonathan Kimmel, Carley Kimmel, and Jill Kimmel.
- Is the middle of three children of Michael and Michelle McNearney.
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