- He has a PhD in astrophysics from Cambridge University, an MD from Université Laval (Quebec City), and completed his family medicine residency at McGill University. He formerly worked as a physician and co-chief of medicine at a health center in Nunavik, an Inuit community on Hudson Bay.
- He grew up in St-Lambert near Montreal, Quebec.
- His hobbies include mountaineering, cycling, skiing, and sailing. He has a commercial pilot's license and an advanced scuba-diving license.
- He is a Canadian astronaut, scheduled to launch on his first space mission in December 2018, along with American Anne McClain and Russian Oleg Kononenko. They will be going up on a Soyuz rocket to the International Space Station. Saint-Jacques will serve as co-pilot and crew's doctor.
- Dr. Saint-Jacques was awarded the O.C. (Officer of the Order of Canada) on November 9, 2022 from the Canadian Governor General. He lives in Montreal, Quebec, Canada.
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