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- The sole survivor of a pier shoot-out tells the story of how a notorious criminal influenced the events that began with five criminals meeting in a seemingly random police lineup.
- A boy blackmails his neighbor after suspecting him to be a Nazi war criminal.
- In a world where mutants (evolved super-powered humans) exist and are discriminated against, two groups form for an inevitable clash: the supremacist Brotherhood, and the pacifist X-Men.
- When anti-mutant Colonel William Stryker kidnaps Professor X and attacks his school, the X-Men must ally with their archenemy Magneto to stop him.
- Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- A college boy whose low blood pressure does not respond with IV fluids piques House's curiosity. Clinic Cases: A woman who had a cold last week, man with a sore throat, woman whose leg hurts after running 6 miles, a boy and his MP3 Player.
- A nun suffering from acute dermatitis and asthma treated by House with possibly the wrong medication comes dangerously close to death.
- A 38-year-old mother, apparently suffering from thrombosis, alcoholism and schizophrenia, has only her young son as caregiver.
- A woman comes down with symptoms of African sleeping sickness, but there seems to be no way she could have contracted it. House and his aides must ask a few tough questions and make some tough decisions in order to try to save her.
- A detoxed sports star about to make his comeback breaks his arm due to brittle bones. Clinic Cases: Woman with leg pain, man trying to remove his contact lenses, a dentist with various issues, and a hung over teenager - all in 70 seconds.
- A morbidly obese ten-year-old girl has a heart attack, and her mother insists that House and his team look past her weight to find the diagnosis. Meanwhile, Vogler pressures House to fire a member of his staff. Clinic Patients: Unidentified man with an infected pierced scrotum; overweight woman with a 30-pound tumor on her ovaries who refuses to have it removed, because she worries she will be unattractive.
- An ambitious and charismatic Black senator campaigning for the presidency falls ill from a mysterious malady, possibly AIDS.
- While House and his team scramble to discover what's causing brain and kidney dysfunction in a pregnant woman, Vogler is on the warpath to get House fired.
- House has to deal with his promised dinner date with Cameron, a mysterious stroke in a clinic patient and a libidinous senior citizen.
- House's ex Stacy Warner asks him to treat her husband. House takes over a diagnostics class for a day and presents the class with three case studies of leg pain. As House tells his story and the class gradually fills up with listeners, the class learns a lot about how to be better doctors, and Chase, Foreman and Cameron learn some important details of House's past.
- House treats a patient on death row while Dr. Cameron avoids telling a patient she has a terminal illness.
- Cuddy joins the team after her handyman falls off of her roof and begins to develop bizarre symptoms. Clinic Cases: African American man who objects to "minority meds."
- A doctor campaigns against the epidemic of TB in Africa, possibly at the risk of his own life.
- The team takes care of a student with inexplicable electrical shocks, and House's parents visit.
- Chaos ensues after Chase's negligence leads to the death of a female patient. Now, after an inquiry from the hospital board, and a subpoena from the patient's brother, it's up to Stacey to protect Chase's career, as well as House's.
- A shipping magnate hires four experts from various fields to investigate what happened to his ships that went missing in the Bermuda Triangle. The team discovers a threat that might unravel time itself and cause the world to end.
- Shipping magnate hires a journalist, a female oceanographer, a psychic and a meteorologist to find out why some of his ships went missing in the Bermuda Triangle. The survivor of one such incident realizes that his reality has altered.
- The team is taken in by the men in black and later released. Howard and Stan search for the plane crash survivor's grandfather, while Bruce and Emily look for the source of the anomalies in the Triangle. Confused Meeno becomes suicidal.
- U.S. Secretary of the Navy has found a way to stop the Triangle phenomena. With their job done, the team goes home only to realize that a possible miscalculation in his plan could bring about the end of the world. Can the team stop it?
- When a famous writer is brought in with language difficulties, House must assist via phone while waiting for a delayed plane.
- House and the team must determine what is causing an increasingly deceitful patient's muscle flailing. Stacy makes a decision, and Cameron avoids a test.
- A patient with 40% body burns and inexplicable cardiac and neurological signs is treated by the team, while House pursues disproving an old enemy's medical study.
- Cameron gets mad at Foreman because Foreman steals his idea for an article. The case of the week: a lesbian woman has not slept for ten days despite taking a bottle of sleeping pills.
- House takes on a teenage faith healer, Wilson desperately wants into a poker game, and tensions escalate between Cameron and Foreman.