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- A young police officer must prevent a bomb exploding aboard a city bus by keeping its speed above 50 mph.
- Hollywood makes a deal with Mexican revolutionary Pancho Villa to film his war and recreate his life.
- Daisy Lowendahl (Bergen) is a best-selling suspense novelist who finds herself at her isolated beach house with a local young fan (Hall) who knows almost everything about her, and two men - one of whom may be trying to kill her, the other of whom could save her life, causing Daisy to be thrown into the middle of a real-life drama.
- When LAX receives word from Homeland Security that a credible threat has put the airport on high alert, Harley and Roger debate over whether to notify the public or continue to keep the news a secret. Tensions build when passengers are faced with longer lines due to extra security, and Roger puts his relationship with his daughter in jeopardy when he refuses to let her fly -- forcing her to miss a very important recital. Meanwhile, Tony must take care of a senile old woman who has been left stranded at the airport by her son who can no longer bear the burden of taking care of her. Elsewhere, Henry loses his gun.
- When a coffin arriving as baggage on an in-bound flight from Grenada is discovered to contain a living person, Harley and Roger with the help of Henry, Betty and Nick locate the missing corpse/stow-away. Elsewhere, Tony tries to secure twelve seats to Albany for a little league team trying to make their first national championship, while the airport staff tests out new tactics to deal with the airports bird problem.
- On his way home from a conference in Sacramento with a quick jaunt to Las Vegas, Roger begins to suspect his plane might be in trouble when a minor electrical surge sets off the cabin call lights. Using his status as LAX tower supervisor and experience as a flight engineer, he attempts to gain control of the situation, only to discover the plane is experiencing a massive power failure as the control instruments slowly start to fail. In the LAX control tower, Harley attempts to guide the distressed plane in for a safe landing while Tony keeps Roger's wife Monique comforted in the terminal and Eddie's fear of flying class is thrust into the ensuing emergency.
- A drama centered on the personal and professional lives of five surgical interns and their supervisors.
- A group of criminal profilers who work for the FBI as members of its Behavioral Analysis Unit (BAU) using behavioral analysis and profiling to help investigate crimes and find the suspect known as the unsub.
- The fabled romantic Giacomo Casanova, after failing to win the affection of the Venetian woman Francesca Bruni, strives to discover the real meaning of love.
- The stirring true story of Franklin D. Roosevelt's battle with polio in 1921.
- The team are called to an Arizona college when an arsonist who operates in a very unusual way kills a student.
- A paranoid schizophrenic takes other passengers on a train hostage, including Elle.
- The team travels to Seattle to find the captor of four missing women.
- A serial rapist-killer active in San Diego targeting middle class women glues his victims eyes open.
- A bomber in Palm Beach forces Gideon to confront an old adversary.
- The first shift for new surgical interns Meredith, Cristina, Izzie, George, and Alex proves eventful and backbreaking.
- A storm rages, causing power outages and jamming the elevator, trapping George and Alex inside with a vulnerable patient. Meanwhile, Meredith and Derek arrange a religious ritual for a young woman, and Cristina deals with an unusual case.
- Cristina is determined to get back to work, and despite not being fully recovered, she manages to crack an odd case. Meanwhile, Addison offers to help Bailey with a complicated surgery, and Alex receives important news.
- A family is admitted after being involved in a car crash, but there is more to them than meets the eye. Meanwhile, Bailey and her team deal with a strange case, and relationship woes plague Meredith, Cristina and George.
- 2005– 1hTV-148.1 (1.4K)TV EpisodeChristmas hits Seattle, with Izzie caring for a man who fell from his roof while hanging decorations. Meanwhile, Cristina helps perform a heart transplant on a depressed boy, and George has to contend with the family from Hell.
- A woman with a massive tumor is admitted, with all the surgeons required to scrub in. In their absence, Meredith is assigned a patient with Parkinson's and, because Alex's pager is not working, Izzie is left in charge of the floor herself.
- A train wreck brings in multiple casualties, leaving Meredith hanging for her answer. Meanwhile, Alex finds working without his mojo a disheartening experience, and Cristina searches high and low for a missing appendage.
- Friends of Derek and Addison come from New York for a preventative surgery that causes discord among both couples. Meanwhile, George helps a man who has fallen from a roof, and Bailey delivers news to the Chief.
- Meredith is horrified when her mother is admitted, and everyone is concerned when Cristina collapses in the operating room. Meanwhile, Addison is determined to save a very sick baby.
- Meredith's one night stand causes complications when he shows up at the hospital with an embarrassing problem. Meanwhile, Burke tries to push Cristina toward the next step, and Alex's problems affect his performance.
- Alex uses Izzie's modeling against her, and her last ad causes a patient to reject her care. Meredith finds parallels between a patient and her mother, and Christina must deal with a hospital-savvy patient.
- The mother of the quints blames herself. Meanwhile, Izzy becomes attached to her patient, Karev must face the consequences of his actions, and Cristina takes care of an inmate desperate to stay at the hospital.
- 2005– 43mTV-148.3 (1.7K)TV EpisodeMeredith, shattered by revelations, is forced to work with Addison, Joe collapses at the bar, Cristina has some pretty shattering news of her own, and Alex starts working on Izzie.
- Meredith wants to learn more about Derek, but he remains cagey. Meanwhile, a supposedly psychic patient proves bothersome, Alex must convince a young girl to agree to a life saving operation, and Cristina is conflicted about her pregnancy.
- Meredith worries she did something wrong during a heart bypass, an error in a past procedure is discovered, putting a staff member's conduct under scrutiny, while a party thrown by Izzie to introduce her boyfriend becomes a fiasco.
- Derek reluctantly attends marriage counseling with Addison, while Meredith, Izzie and Cristina steal a patient with an unusual problem. Alex helps a young patient gain her independence, and Cristina thinks Bailey knows about her and Burke.
- Thanksgiving sends the occupants of Meredith's house in different directions: Meredith escapes to the hospital, George goes hunting with his family, and Izzie throws a dinner to which it appears no one is coming.
- A rape victim is admitted, who managed to hold onto part of her attacker; Izzie has difficulty with a patient who cannot speak English; Meredith becomes concerned about a sick baby.
- Izzie and George find out about Meredith and Derek, while Cristina makes a discovery of her own. George thinks an anesthesiologist is drinking on the job, and Meredith deals with a young girl who has had illegal surgery.
- George finally gets laid but gets syphilis. It's rampant among staff. Surgeon Webber is losing his sight. He wants Shepherd to operate secretly. A male patient has an ovary. A lifesaving autopsy's performed without consent.
- Izzie and Cristina are assigned a close-to-brain-dead John Doe who may be a viable candidate for organ donation, and helpful to George's patient, who needs a new liver. Meanwhile, Meredith and Alex butt heads over a patient of their own.
- Dr Walter gets married to the beautiful Kitty but soon finds out that she is cheating on him. Battling his way through problems, he heads to China to fight a dreaded disease spread in a small village.
- In what would cause a fantastic media frenzy, Clifford Irving sells his bogus biography of Howard Hughes to a premiere publishing house in the early 1970s.
- A conflict mounts between a Midwest farming community and the U.S. government escalating to a modern-day civil war.
- The team must determine whether an abducted girl is the pawn in a bitter divorce, or something more sinister has happened.
- The team of investigators interview husband and wife serial killers with their execution date set for two days time.
- In town to conduct a seminar, Gideon and Reid become involved in a stalker case that has escalated to murder.
- Meredith considers going on a date with Finn, and Izzie tries to find out more about George and Callie. Meanwhile, Alex clashes with Addison over a sensitive case, and Burke is nervous about operating on a patient who is one of his heroes.
- The BAU team investigates a CIA counter-terrorism unit to identify a traitor who had a fellow agent murdered and who is trying to find and kill the unit's informant, a Saudi woman with two children who are in hiding.
- Team members become pawns of a psychopathic killer.
- Elle's fate is unknown, and the unsub continues dropping clues as the team scrambles to identify him before another tragedy occurs.
- The BAU team investigates a series of murders in Florida, suspecting a partnership between two deviant persons with complementary personalities due to the nature of torture videos taken of the victims sent to the victims' parents.
- The team flies to Los Angeles to pursue a bank robber who is quickly disintegrating into an enraged sexually-motivated spree killer.
- While the team profiles a killer in a small town, Hotch must stay and deal with Elle who is beginning to unravel.