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- The permanent closure of ward 17 heralds the end of an era and generates much uncertainty among the nursing staff.
- It's Von's last day and while the rest of the team struggle to get through another day, she is determined to leave with a win.
- The Ward 17 crew deal with a former school teacher, while Terri looks after a young Muslim with high blood pressure. And the team also deal with an epileptic patient who has gone off her medication.
- As Ward 17 celebrates Christmas, a sick child hopes that her wish will come true, an elderly man asks Santa for a special gift for his ailing wife, and Bronwyn is in for a surprise.
- Lu tries to help injured single mom, Melissa Nauls, who's addicted to Crystal Meth keep custody of her three kids. But when Melissa dies after going back to a crystal meth lab Lu has to find a way to keep all three kids together as Christmas approaches. Meanwhile, Kayla is attracted to blind patient Will Manning which makes Peter very jealous.
- Christina invites Forrest and his children to her Christmas party. Lilly finds the holidays difficult to bear after she is brutally beaten by a freedom-bus protester and Paul Slocum finds Christmas cheer in an unlikely place - Coach Zollicofer Weed's circle of friends.
- Kayla loses a patient who was a bank robber, only for his unstable girlfriend Jamie to show up at the hospital with a bomb strapped to her body. Meanwhile, 35-week pregnant Sirena Adkins is brought in suffering from meningitis and her mom tells Lu to only save the daughter and not the baby.
- Called out to a car accident, Ben and Bronwyn are horrified to find one of their own is involved.
- All Saints is thrown into emergency status when an explosion creates chaos and carnage. The disaster becomes personal when the staff realise that Von is missing.
- Julie's water breaks whilst she is out shopping. With Eric away on business, Julie asks Andrew and Lauren to be present at the birth. Meanwhile, Danny takes over Andrew & Lauren's holiday suite. Later, Julie gives birth to a boy named Perry.
- Connor stands in for Kate on a quiet night on the ward. He and Bron fool around as Jared tries to study, but then things start to go wrong. Meanwhile, Von watches her friend Kate finally succumb to the horrors of alcoholism.
- Emotions run high in Ward 17 when the staff discover the bomber is a patient and Terri's life is on the line.
- The Winchester brothers seek the help of their family friend Bobby while investigating a series of unexplained happenings on a local college campus.
- Sam and other "special children" are abducted by the Yellow-Eyed Demon and taken to a ghost town, where the ultimate battle must start.
- David Robert Jones comes out of hiding following an attempt on Nina Sharp's life while Walter leaves accompanied by the mysterious Observer.
- When Regionals finally arrive, Sue pulls a fast one on the Glee Club, and their chances at the title could be compromised.
- Andy treats Victor, a car crash patient who's dying from ALS (amyotrophic lateral sclerosis) who wants to die from his injuries so his organs can be used to save others at Three Rivers. Meanwhile, David deals with the parent of three young foster children, suffering from pulmonary hypertension, who refuses to be admitted into the hospital. Miranda deals with a former heart recipient, named Barbara, who's new heart begins to cause complications, while Ryan is stuck with planning a donors-recipients reception at the hospital.
- It's a heartbreaking time for Samantha when her mother's condition worsens. Mitch uses his voodoo skills to help a deluded patient.
- Mitch is forced to confront his fears when a cancer patient refuses treatment. Stephanie gets starry-eyed about a possible promotion.
- Terri, Peter and Ron find themselves in a siege situation when Sophie cracks. Bronwyn's fundraising netball game disintegrates. Von's New Year's resolution seems destined to go up in smoke.
- Dr. Campbell treats Rachel, a patient she believes is an alcoholic but she won't admit to her drinking problem. The patient's daughter Jordan goes to desperate measure to get her mom to stop drinking. Another of Andy's patients needs to get a kidney transplant but nobody in her family is a match. Tammy's mom then reveals a horrible secret that could save her daughter's life - she was raped and her daughter is the product of that rape. Meanwhile, Lu, Lana, Peter, and Ben go out on the streets to find out what is threatening the lives of young infants.
- Lauren doesn't want to tell about her pregnancy at work, but tells anyway. She takes on more work because she wants to prove she needs no special treatment. But she suffers from forgetfulness and drowsiness, so things become difficult.
- With Mike out of action, Steve's leadership abilities are put to the test while rescuing two brothers trapped in a lift. A fathers decision with regard to his daughter leaves Charlotte feeling hamstrung.
- As the All Saints staff are kicking up their heels at the Hospital Fundraising Ball, Terri battles an obsessed ex-patient.
- Richard Craig is all set to perform ground breaking heart surgery, but when the patient changes his mind, Richard places the blame on Bronwyn.
- Terri's grief reaches a climax when she ends up in hospital suffering from pneumonia.
- Luke, Bron and Ben must overcome their personal differences in a cliff-side battle to save a young man's life.
- Ben and Bronwyn are called to save a little girl who has fallen down a storm water drain. Terri reveals another side to her nature when a patient pushes her too far.
- When 2 teenagers are brought into the ward after a home made bomb exploded at a state boy's school, their different attitudes lead to a number of wrong conclusions being drawn.
- Professional boundaries are overstepped when Mitch and Luke clash over treatment for a girl with an aneurysm.
- An horrific accident brings a family into the Emergency Department, and Terri finds herself spending her last day at All Saints on a crusade to alleviate a young girl's guilt. Her last day is fraught with complications as a family's celebration goes horribly wrong and their hot-air balloon crashes in dense bushland. The All Saints team find itself juggling multiple casualties as well as the news that a member of the family has gone missing at the scene. Terri nurses the daughter of the woman the team could not save and finds her patient is burdened with survivor guilt. Frank urges her to keep her distance and refrain from seeing this as her last crusade, but Terri can't walk away. As the day wears on, Terri says her goodbyes to those she's closest to but Jack keeps his distance. She soon discovers that she can confidently hand over responsibilities to Nelson and the team she has come to know and trust. As the All Saints chapter of Terri Sullivan's career closes, her farewell celebrations turn sour when Vincent's past catches up with him. It would appear that Beth Chandler's strategy has changed - she is now looking to target those around him. His friends in the Emergency Department are now open targets.
- The mercury is pushing 41 degrees, bushfires are raging and tempers are fraying. While Ben and his new partner, Scott, are trapped in the path of a deadly blaze, the hospital staff are crying out for a cool change. Terri makes a major decision with her life while nursing a man with severe burn injuries. Meanwhile, Connor finds it difficult working with Bron after his attemp to woo her fails.
- Andy tells Amber Seale, a famous rock star, and a patient to rest and cancel some of her concerts because of fatigue. The rock star invites Lu's young patient Lily who has a terminal disease to spend the day with her. Lu's patient's mother directs a terrible accusation at the rock star. Ben starts a concierge service to keep the clinic open after it faces financial difficulties.
- Now the pregnancy is a fact, Andrew frantically plans savings to put their kid trough college even if it's a genius requiring special schooling. Alas the idea of Lauren not returning to work catches on with her before Danny can make Anderw understand it would make life unbearable for them and Hector, as gardening events make painfully obvious.
- Arriving late for work Frank is forced to cut short a conversation with a grieving parent to assist with an incoming MVA patient who is a prisoner who was being transferred to court when the prison van rolled.
- Bart is mortified when Amy comes up with a controversial solution for a patient who looks likely to die a virgin.
- A woman presents having suffered a miscarriage. A history of SIDS with two previous babies throws a raft of distressing possibilities at Von and Charlotte.
- Tracy Allen is the wife of a San Francisco billionaire who arrives at Three Rivers in need of a new liver. But complications set in when David and Pam travel to Youngstown, Ohio to pick up one from the donor, a murder victim of highwaymen, a setback occurs when the liver is cancer ridden. As a result, Tracy's husband, John, defies Dr. Jordan's advice and resorts to buying a new liver for her on the black market. Meanwhile, a friend from Andy's criminal past, named Michael, resurfaces who anonymously gives a hearty donation to the hospital for Kuol's heart transplant as a bargaining chip to get Andy to resume his old life of crime before entering med school. Also, Miranda and Andy try to treat a young couple who are infected by an unknown pathogen.
- An unknown aggrieved man shoots new bride to be Kim Mullins. Her new husband Sam agrees to organ donation when she is declared brain dead but her mother Nancy is against it and gets a court order to stop Sam. Miranda goes out of her way to find lungs for her patient Mark Wilson and goes to South Carolina in the hope of harvesting Kim's organs and college basketball player Anton Weathers needs a new heart and hopes to benefit from Kim also but is devastated when he finds he will not be able to go pro after his transplant.
- The rapist strikes again, kidnapping Bron and leaving a young nurse dead. Ward 17 is threatened with quarantine after a breakout of golden staph amongst patients. Luke is forbidden to operate on patients after being suspected as a golden staph carrier. In mortal danger, Bron is shocked when she discovers the identity of the serial rapist.
- Terri finds herself unable to separate professional ethics from her personal beliefs when a witch is admitted to the ward.
- While Stephanie tries to adjust to the idea of being pregnant, she is assigned to nurse a dying woman who wants to hold on for the birth of her grandchild.
- Bronwyn is given a glimpse of what her future could be like with Luke. Meanwhile, the ward is in fierce competition as they prepare for battle in the annual All Saints fund-raising bed race.
- Vincent elects to spend the weekend with grace to help out back in her home town with her father. Partly to help and partly because of his growing feelings for her.
- Terri has been up all night comforting Peter who cannot accept that his wife is brain-dead. She also has the difficult task of asking Peter to give consent for Jenny's organs to be donated.
- Stephanie and Luke work together to solve a medical mystery but with devastating consequences. Terri has to deal with a nudist on the ward. Bronwyn realises Ben has post traumatic stress syndrome.
- Ward 17 reels from the consequences when they learn about Jaz's ordeal. Ben discovers an elderly patient who isn't at all what she appears to be.
- Bron hates goodbyes but it's going to be hard to avoid them. All she wants is an easy day at work but that doesn't seem likely with one of her patients having his arm amputated.
- Cate's early morning visit with Mac sours and sets the tone of her entire day. Back down in the Emergency Department, Cate comes face to face with a past unresolved situation when a prostitute is brought in brutally bashed. When Cate finds out the patient is the mother of the child she saw in a brothel [episode 7.35], she rushes in where angels fear to tread. Engaging Nelson's help to get the Department of Child Services on side, Cate launches into her quest to save the child, Lily. Nelson watches with concern as Cate's objectivity is brought into question. It takes an extraordinary offer for Nelson to understand the depth of the situation. When all options are exhausted both Cate and Nelson feel drained and unfulfilled as their efforts result in a no-win situation for all concerned. Jack is tending to a woman with a self-inflicted injury after a road rage incident. In treating this woman, Jack is forced to think more carefully about his behaviour when dealing with the emotional rollercoaster he is on with Charlotte and their unborn child. It's all going too fast and the child somehow seems unreal. The situation is complicated by the fact that Charlotte's pregnancy is now common knowledge and Jack's role in it is already known to Frank Campion. Frank, a party to all these events, has to re-evaluate his own role as a parent. Kathleen is recovering and asks to see him. When he visits, he learns her mother has been to see Kathleen several times too. An angry confrontation settles nothing. Lily's unfolding plight gives Frank food for thought and even though he's not able to make a rapprochement with Alison herself, he does find himself beginning to make room for her in their daughter's life.