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- A crook on the run hooks up with a criminal gang to commit a kidnapping. However, things don't go quite as planned.
- Neela's marathon shift begins to affect her, and her demeanor isn't helped when she learns the med student she is mentoring is abandoning her specialty.
- An evil high-fashion designer plots to steal dalmatian puppies in order to make an extravagant fur coat but creates an extravagant mess instead.
- Cruella DeVil gets out of prison and goes after the puppies once more.
- The pilot for the popular TV series is set during 24 frantic hours in the lives of a group of doctors, nurses, and staff members of a busy emergency room at a Chicago hospital. They deal with the seemingly endless casualties that stumble into their place of employment. The central characters are the chief resident and family man Dr. Mark Greene, who is considering a job in private practice due to pressure from his demanding law student wife Jennifer; outgoing Dr. Doug Ross, who deals with cases in his own personal way; straight-arrow Dr. Susan Lewis, trying to get by another long 36-hour shift; inexperienced third-year med student John Carter; cocky surgical resident Dr. Peter Benton; and troubled chief nurse Carol Hathaway.
- A dying CIA agent trying to reconnect with his estranged daughter is offered an experimental drug that could save his life in exchange for one last assignment.
- Morning shift begins. The night shift treated 142 patients - a new record. Dr. Morris is confident that by the end of the day the ER can set a new record of 300 patients. Frank reminds him that there has never been more than 250 patients in a day. Dr. Morris bets $300 that they can reach 300 by the end of the shift. Frank, Dr. Gates and Dr. Pratt each bet $100 against him. But will the game be fair? Also, when chaplain Dupree arrives announcing that she's doing a round of the hospital, holding blessing ceremonies and memorials, the guys are against it, except for Dr. Gates, which makes the others suspicious. Frank goes straight to the point. Then there is the accident involving a camel.
- Susan Lewis' boyfriend Div Cvetic, a psychiatric resident at County General, seems to be under a great deal of stress regularly lashing out at everyone. Doug Ross takes over for Mark Greene who takes a day off to be with his wife. He has a hard time keeping up with all the paperwork. John Carter is increasingly frustrated with Peter Benton who never seems to invite him to participate in surgeries. Benton learns the result of the fellowship he applied for and his mother shows up in the ER with a sprained ankle. Carol Hathaway treats a patient who was raped. A new ER aide, Bob, start work.
- A Kansas family relocates to Beverly Hills, where their two children adapt to the infamous social drama of West Beverly Hills High.
- Dr. David Morgenstern returns after a six-month absence recovering from his heart attack. His new outlook on life however has Kerry Weaver questioning his abilities. Elizabeth Corday decides to start a study on the use of artificial blood in the ER, but the only problem is that she fails to discuss it first with Rocket Romano. Doug Ross decides to apply for an ER attending position. Scott Anspaugh suffers a major relapse. Anna Del Amico is confronted by an irate husband who wants his ill wife to terminate her pregnancy. At the free clinic, Carol Hathaway has to deal with the case of an underage high school student who is sleeping with her 40-year-old teacher. Peter Benton hits a pedestrian with a car but Carter helps him out with an important piece of information.
- Abby comes close to breaking down trying to deal with her mother. Dr. Pratt goes for his required paramedic ride-along. Dr. Weaver confronts the man who stole her purse. Dr. Lewis has a teen admirer.