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- A truck driver tries to figure out what happened when a woman hitchhiker he picked up is later found run over in the road.
- Six student nurses start training in the NHS, facing challenges working with colleagues and patients while adapting to the hierarchy and procedures.
- Student Nurses Longhurst and Rutherford both have clashes with authority. In an appraisal, Sister Easby accuses Nurse Longhurst of getting too involved with patients and lacking detachment. She takes these accusations very badly, feeling that she has been misjudged and victimized by an unfair appraisal system. Meanwhile, Nurse Rutherford is irritated by what she sees as unnecessary, irrelevant teaching, and nursing lecturer Miss Windrup targets her for her perceived lack of attentiveness.
- Student nurses are starting their courses at St Angela's Hospital. Flighty upper middle class Patricia Rutherford seems to have the biggest transition to make. Maureen Morahan has a much more earnest approach and has travelled from rural Ireland. The newcomers struggle to get to grips with their practical rather than fashionable uniforms. By contrast second year students Jo Longhurst and Shirley Brent go about their work on the wards with confidence and good humour.
- Jo Longhurst has chosen Mr. Collins for her case history but has she made a wise choice? He is an extremely difficult patient, very bitter at his illness and snapping angrily at the nurses and fellow patients, especially Mr. Slingsby who remains upbeat and seems to delight in talking about his treatment in graphic detail.
- It's the end of the nursing year and a time for the student nurses to look to their future. For some of them it's a look forward to a career as a staff nurse or towards a future specialism. However for one of them an incident with a notoriously difficult patient may mark the end of her career before it's barely begun.
- Sister Young accuses head porter Harry Jamieson of carelessly transporting a patient. In protest he calls all the porters out on strike. The incident is witnessed by junior nurse Ruth Fullman and places her in a very difficult position, amplified by her desire to be promoted to the position of staff nurse for which she will need her Sister's recommendation.
- The student nurses are excitedly receiving their exam results and most of them are in a state of celebration. However senior student nurse Shirley Brent misses the morning post and events during the day make her wonder whether she cares whether or not she has passed.
- Young nurse Linda Hollis sees her marriage to Brian, a student, come under severe strain as he becomes increasingly frustrated with the demands of her career. Meanwhile first year student nurses come into contact with patients on the wards for the first time.
- For most people leaving hospital is a relief but not for Mr. Pettit who is terrified of the prospect and refuses to leave. Social worker Sarah Tuddenham tries to help him and discovers his problems are social rather than medical. Elsewhere the busy and cheery exterior of nursing lecturer Miss Windrop hides a woman craving for company while Jo Longhurst is persuaded by Ruth Fullman to invite the standoffish Shirley Brent to a party.
- Nurse Ruth Fullman has a difficult time on the night shift. She feels uncomfortable with agency nurse Audrey Steiner with neither seeming to trust the other. Dr. Crozier brightens up her evening but even this brings her into conflict with the Number 7 and later all the ward staff have to deal with an emergency.
- Maureen takes Patricia to see her Aunt Kath and then the pair visit a pub. Patricia finds the night livened up by meeting up with Maureen's cousin Barney but they also encounter Beryl, a former nurse at St Angela's, who feels rather in the need of company and may not have left the hospital as far behind as it first seems.
- Ruth Fullman is pleased when her friend and former colleague Clare Truman arrives as a maternity patient. Clare, with her husband and new baby, seems to show that there is a very fulfilling life outside nursing; however she may not be as happy as she first appears. Meanwhile Nurse Morahan is worried about her personal finances.
- Jo Longhurst invites the withdrawn and intense Shirley Brent to a party where she meets up with an equally ill at ease male nurse. Jo attracts an admirer but is he the right man for her? Meanwhile a young doctor tries to persuade Sita to attend while for two other nurses actually reaching the party proves to be quite a challenge.
- Young Staff Nurse Linda Hollis finds that managing a busy, unpredictable ward doesn't always sit with well with married life. Meanwhile two of her Student Nurses Jo Longhurst and Shirley Brent are having a fractious relationship with Jo irritated by Shirley's officious and abrasive character. However Jo can sense that Shirley is lonely and tries to adopt a more friendly and supportive attitude that might make her more amenable.
- Sandra Ling has to deal with an emergency at her factory when a worker suffers life threatening injuries when equipment malfunctions and sprays him with the dangerous chemical phenol. The malfunction was no accident and was caused by another worker's sabotage. Meanwhile both Jo Longhurst and Shirley Brent are having uneasy relationships with more senior staff. Jo feels constantly criticised by Sister Ashton while Shirley's motives for working on the Psychiatric Ward are questioned by Dr. Berry.
- Shirley Brent is having great success connecting with the patients on the geriatric ward, showing a liking for such work unlike most of her colleagues. However things are going anything but smoothly for the previously accomplished Alison Salter whose erratic performance is giving cause for concern, perhaps because she has matters other than nursing very much on her mind.
- Life on the psychiatric ward can be a trial for everyone, with the patients frequently at each others' throats. Shirley sees this as her vocation but Pat Rutherford mocks her involvement and Shirley herself starts to wonder if she is really cut out for such work.
- Pat Rutherford tries to arrange a wedding ceremony for Mrs. Sheppard who is terminally ill but her well-intentioned plan meets a number of obstacles. Jo and Sita have their work cut out dealing with the prickly Keith Aldiss, a very well-informed but awkward patient. Sister Bodinetz gives Jo a run as nurse in charge but being in authority has its pitfalls as well as its benefits.
- The older patients attend a concert but it is not for all of them an enjoyable time. Jo Longhurst replaces Shirley Brent on the shift and finds it an eye-opening experience. Shirley is away sharing an evening with a male friend who is about to go away but will it prove a night to remember?
- The nurses are working with elderly patients, encountering a range of characters and experiences. Pat Rutherford develops a close relationship with Dodie but other patients prove rather more difficult to handle. In one instance one of them suffers a broken leg, apparently when being moved, and the possibility of negligence or even abuse rears its head.
- Maternity is the theme. Mrs. Clark is rushed to hospital in labour and is worried to discover that her birth will be more complicated than usual. Sandra Ling - who is interested in a career in occupational health - discovers that a sixteen year old factory worker called Barbara Swainson is pregnant. Barbara is very concerned about her father's reaction; Sandra tries to make this easier for her but will she be successful?
- Maureen and Pat get the chance to return to their families for a break. Maureen is particularly pleased to return to Ireland, including seeing boyfriend Michael, but notices a tension with her younger sister Kate. Pat visits her upper middle class family near Bath and hears some alarming revelations about her parents.
- Shirley Brent has a difficult time dealing with Diana, a drug addict, squatter and a frequent patient. Diana has some harsh things to say to Shirley who struggles to keep composed. However Shirley has more success with another regular patient, the elderly Miss Buckle, whose ailments may not be all they seem.
- A new year brings changes for many of the nurses including a new positive attitude from the previously disaffected Pat Rutherford. However she and the other nurses have their work cut out coping with a young boy suffering from meningitis and his mother who is struggling to come to terms with his serious illness. Sita Patel receives an unexpected ticking-off from one of the Sisters while Shirley Brent also finds her conduct causing concern after she snaps at a patient's relative.
- A harrowing incident with a patient leaves Sandra Ling very shaken but she is shocked by the sense of detachment of one of her colleagues. Joan White organises a get-together to mark thirty years in nursing for Heather Windrup. Is this though really a cause for celebration or an opportunity for soul-searching? Is Heather still able to connect with the students of today?
- Maureen joins community health nurse June Morris on her rounds. In contrast to the cheery June, Maureen seems very unimpressed with the patients and their dour environments. Pat Rutherford detects a change for the worse in the previously non-judgemental Maureen; however a visit to retired teacher and alcoholic Jack Knight gives her pause for thought.
- Maureen and Pat decide to find their own flat outside of the nurses' quarters but are they really suited to living together? The solitary Heather Windrup gets a rare chance for some company but will her visitor live up to expectation? The weekend though is still a working time for Jo Longhurst and she tries to raise the spirits of a depressed patient by arranging a rare visit from her brother but should a nurse visit the home of a patient's relative?