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- Colette and Aaron have a long history of heroin addiction, which they've been able to kick with the aid of methadone. But now that Colette's pregnant, she's finding that it's possibly riskier to go off the methadone during pregnancy, than to stay on it.
- Misty and Jonathan lost their home shortly after Misty became pregnant. Now, the couple lives in a tent in the woods and struggle to find jobs and housing before the baby is born, or they risk losing custody of him.
- Beth has always wanted children, but being pregnant isn't easy for someone with an eating disorder. She turns to her husband and therapy for help because if she gives into undereating and over-exercising, she could put herself and her baby at risk.
- Nicole's husband, Mike, has achondroplasia dwarfism and their baby has a 50-50 chance of being born with the condition. The couple plans for either scenario while learning all they can about dwarfism before the birth of their child.
- Trisha has spent her pregnancy behind bars for dealing and using drugs. Up for parole, she will soon discover if she will give birth in jail or have a chance to prove that she can conquer her addiction and be the mother her child needs.
- Raine struggles to clear her house of clutter before her baby is born, but it isn't easy. She suffers from hoarding, but knows that despite her compulsion, it is crucial for her baby's safety to clean up her act before the birth of her son.
- On the outside looking in, Tashala appears to be a normal pregnant woman, but she isn't. Tashala is HIV-positive and pregnant for the second time. Thankfully, her first child did not contract the virus, but will her second baby be as lucky?
- Mindy discovered she had cervical cancer in the first trimester of her pregnancy. Instead of aborting the pregnancy to receive treatment, she chose to keep her baby. Now, Mindy waits to find out who will win this dangerous gamble.
- Many pregnant women are self-conscious about their changing bodies, but not Sherri. Sherri is a third-generation nudist. As her delivery day approaches, she now must decide if she wants her daughter to continue the family legacy.
- Shanice is pregnant with her second child. She is also super morbidly obese with a BMI of over 50 percent. Shanice knows she must change her lifestyle and eating habits to ensure that she'll be there to see her kids grow up, but it isn't easy.
- Jenna's life is dominated by fear of contamination OCD, also known as Obsessive-Compulsive Disorder. With a second child on the way, she struggles with a condition that worsens with pregnancy and dictates both her marriage and young son's life.
- Kathleen Steele has it all. A job she loves, a devoted 63 year old husband, a sailboat, beach house; all, except the children she wants. Now, at the age of 55, she's pregnant with her first child, but nothing about pregnancy at her age is routine or easy.
- When Sarah entered prison, she was 3 months pregnant. Now, she is preparing for another challenge - after the baby is born, she will bring him back to the prison, where he will live with her for the duration of her sentence.
- Jolene and her boyfriend Correy are expecting a baby girl. But being pregnant has meant that Jolene had to choose between taking the psychiatric drugs that control her bi-polar disorder, and safeguarding the health of her unborn child.
- At 4 feet 2 inches, Nadea Fox is coping with the difficulties of being pregnant while having achondroplasia dwarfism. The father of the baby is no longer in her life, but since he is average sized, Nadea may have a full-size baby. Regardless of how big the baby is when he is born, Nadea will be forced have a C-section, as her pelvis is too narrow to give birth any other way. And since her spine is more compressed than that of an average-size woman, complications arise when she is being given the anesthesia for the surgery. Will Nadea and the baby be okay, and what size will the baby be at birth?
- Crystal meth has all but destroyed Katy Irmen's life. Having struggled as a meth addict for the past 10 years, Katy finds herself pregnant. Though she struggles to stay clean, Katy has already relapsed twice during her pregnancy, and is being released from a full-time residential rehab facility to face the realities of her life and her addiction on her own. This episode follows Katy's journey as she returns home, reunites with old friends and confides in fellow addicts. As she struggles with her own recovery, Katy also comes to terms with how her meth addiction may have affected the health of her unborn child. When the baby arrives, Katy must learn to juggle the pressures of caring for a newborn while dealing with the rigorous demands of addiction treatment. If Katy relapses again, she would not only face prison time, she would also lose the most precious thing in her life-her newborn daughter.
- 2009– 22mTV-PG7.3 (7)TV EpisodeOn the surface, Brandy and Josh look like a happy young couple expecting a new baby. But behind closed doors, they are hiding a huge secret-Josh wants to be a woman. For the past six months, Josh has been undergoing treatments to become a woman by taking estrogen shots, while Brandy suffers from trichotillomania, a disorder of obsessive hair pulling, which she covers up with a wig. Will the birth of their son lead Josh to consider the possible repercussions of his gender confusion? Will Josh and Brandy be able to learn how to live honestly with each other and their newborn baby? Or will this family be destroyed by secrets?
- Heather is a 22-year old trucker who is pregnant with her first child. She loves life on the road and plans to bring her newborn along with her once he is born. But can Heather really keep up such a difficult lifestyle with a newborn in tow?
- Jessica loves being a stripper, but pregnancy has kept her off the stage. Her family is financially struggling and they are counting the days until she can get back to making money. But will this mom be able to get back in shape in time to keep her job?
- Mindy discovered she had cervical cancer in the first trimester of her pregnancy. Instead of aborting the pregnancy to receive treatment, she chose to keep her baby. Now, Mindy waits to find out who will win this dangerous gamble.