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- In Montana's wilderness, man poses the greatest threat to drug smugglers crossing the Canadian/American border. Long winters, boredom and isolation, fuel addicts' urgency for drugs.
- A dealer makes a drop at a Hollywood red carpet event; a family hustles paste through a Peruvian forest; a US Customs stealth plane tracks an aircraft landing on a Guatemalan beach; a Border Patrol Agent makes his way through a tiny tunnel under the US-Mexican border as oxygen levels drop. At every step the price goes up, and the risks grow greater. Drugs Inc. reveals the international supply chain of a drug more valuable than gold: cocaine.
- A fireside chat takes place for a group in Oakland while tripping on ecstasy. A gay clubber in San Francisco. A San Diego dealer. A Cambodian conservationist battles denudation of sassafras oil-producing trees. A cook/trafficker in Amsterdam. Border officers in Vancouver, Canada search shipping containers and air parcels. A dealer in Southern California used to make $20,000 weekly. A psychotherapy patient heads to a secret west coast location to use E therapeutically. A Miami paramedic deals with someone having a bad trip at a music festival.
- A center in the Amazon jungle in Peru supplies ayahuasca to tourists seeking healing. A University of San Francisco expert weighs in. A San Francisco undercover narcotics agent, who plies the LSD triangle between Santa Cruz, Berkeley & Haight-Ashbury, suffers brain damage after inadvertent exposure to a high dosage. A New York heroin user turns to ibogaine to kick his habit, and now treats others who want to quit their addiction in Canada (where it's legal). A Texan, suffering from cluster headaches, uses psilocybin (magic mushrooms). A LSD therapist in Switzerland helps a cancer patient overcome her fear of death.
- The gambling mecca Sin City plays host to 40 million tourists a year. In storm drains beneath the Las Vegas strip, homeless addicts get high on crack in underground shanties, while in half-built suburbs, police battle marijuana gangs for control of the city's slump-hit homes.
- In Hawaii, which has one of the highest rates of crystal meth users in the nation, National Geographic Channel cameras follow along on a raid to a drug trafficker's house to discover a woman who continues to deal crystal meth while her husband is in jail.
- New York City is in the grip of a heroin epidemic, as a new generation of middle-class suburbanite dealers hooked on prescription pills switch to heroin, and venture down the Long Island Expressway Â- dubbed the Heroin Highway into urban Brooklyn and Queens to get their fix.
- The devastating consequences of Hurricane Katrina in Louisiana resulted in a wave of small-scale drug dealers taking over the streets of New Orleans. As a means of coping with depression and post-traumatic stress disorder, traumatized locals have turned to cocaine.
- The local drug scene casts a dark shadow on the sunny lifestyle of Puerto Rico, a place where addicts roam the streets in search of their next fix. For Dr. Panelli, treating abusers for jungle rot, a ghastly condition that comes with using injected drugs, can be an overwhelming task.
- The most dangerous city in the USA, Detroit, is a perfect mark for today's growing drug industry. Dealers are learning cater to inner city clientele by selling smaller amounts of hard drugs like heroin and cocaine for single-digit prices.
- Kingston is in the hands of highly organized and warring drug gangs. They manage drug trafficking and distribution at all levels. With the patronage of politicians, they fight hard to protect their turf in a city where poverty and guns drive the drug trade.
- Alaska has a dark secret : it has one of the biggest drug problems in America. We'll get a firsthand look at the effects of heroin and the withdrawal symptoms involved in using the drug.
- Chicago, the biggest open-air crack and heroin market in America is at saturation point. The result: record levels of overdoses and homicides, as gangs fight over drug turf.
- Houston's drug hub is the 'Bloody Nickel' - the Fifth Ward. Five square miles of 24/7 drug and party action. Gangs work across the ethnic divide to keep the drugs flowing; while cops and Cartels vie with each other for control.
- Miami - once America's cocaine capital; but no more. The War on Drugs has hit home. Today dealers and users play cat and mouse with the cops and live in dread of the Feds. And a new look drug scene has gone underground.