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- Neela's marathon shift begins to affect her, and her demeanor isn't helped when she learns the med student she is mentoring is abandoning her specialty.
- The pilot for the popular TV series is set during 24 frantic hours in the lives of a group of doctors, nurses, and staff members of a busy emergency room at a Chicago hospital. They deal with the seemingly endless casualties that stumble into their place of employment. The central characters are the chief resident and family man Dr. Mark Greene, who is considering a job in private practice due to pressure from his demanding law student wife Jennifer; outgoing Dr. Doug Ross, who deals with cases in his own personal way; straight-arrow Dr. Susan Lewis, trying to get by another long 36-hour shift; inexperienced third-year med student John Carter; cocky surgical resident Dr. Peter Benton; and troubled chief nurse Carol Hathaway.
- Morning shift begins. The night shift treated 142 patients - a new record. Dr. Morris is confident that by the end of the day the ER can set a new record of 300 patients. Frank reminds him that there has never been more than 250 patients in a day. Dr. Morris bets $300 that they can reach 300 by the end of the shift. Frank, Dr. Gates and Dr. Pratt each bet $100 against him. But will the game be fair? Also, when chaplain Dupree arrives announcing that she's doing a round of the hospital, holding blessing ceremonies and memorials, the guys are against it, except for Dr. Gates, which makes the others suspicious. Frank goes straight to the point. Then there is the accident involving a camel.
- Susan Lewis' boyfriend Div Cvetic, a psychiatric resident at County General, seems to be under a great deal of stress regularly lashing out at everyone. Doug Ross takes over for Mark Greene who takes a day off to be with his wife. He has a hard time keeping up with all the paperwork. John Carter is increasingly frustrated with Peter Benton who never seems to invite him to participate in surgeries. Benton learns the result of the fellowship he applied for and his mother shows up in the ER with a sprained ankle. Carol Hathaway treats a patient who was raped. A new ER aide, Bob, start work.
- Dr. David Morgenstern returns after a six-month absence recovering from his heart attack. His new outlook on life however has Kerry Weaver questioning his abilities. Elizabeth Corday decides to start a study on the use of artificial blood in the ER, but the only problem is that she fails to discuss it first with Rocket Romano. Doug Ross decides to apply for an ER attending position. Scott Anspaugh suffers a major relapse. Anna Del Amico is confronted by an irate husband who wants his ill wife to terminate her pregnancy. At the free clinic, Carol Hathaway has to deal with the case of an underage high school student who is sleeping with her 40-year-old teacher. Peter Benton hits a pedestrian with a car but Carter helps him out with an important piece of information.
- Abby comes close to breaking down trying to deal with her mother. Dr. Pratt goes for his required paramedic ride-along. Dr. Weaver confronts the man who stole her purse. Dr. Lewis has a teen admirer.
- Needing someone to play Santa Claus for the community center, Chet bribes a surly old man who was recently fired from his job selling Christmas trees.
- While the Seaver family prepares for Christmas, one of Jason's patients contemplates suicide by jumping down the Seaver chimney.
- Chet trys to convince a talented student to join the school's struggling track team, but the student has no interest in joining for personal reasons.
- Plans that are part of a top secret U.S. government project are stolen. An independent operator intends to sell them to an Eastern Bloc nation. But the two sides don't trust one another and each is out to gain any advantage it can. The FBI gets a break when a visiting Eastern bloc scientist - who wants to defect to the U.S. - informs the bureau he has been contacted to help verify the plans. But the scientist is injured in a lab accident before he can see the plans. Erskine takes his place and goes undercover. This time out, things will be even more dangerous for the FBI man. He'll have to fake being blind, like the defecting scientist. The scientist is also an accomplished chess player, something that could blow Erskine's cover.
- A priceless diamond has been stolen from a retired millionaire in Oregon. When evidence emerges the thieves have fled to Northern California, the FBI enters the case. Erskine goes undercover as an associate of the retired millionaire. He is to negotiate for the return of the diamond for a ransom. But when other criminals begin to gather, the situation becomes more complicated, and dangerous, for the FBI man.
- An autistic eight-year-old girl nicknamed Punkin unexpectedly shows up on Chet's front doorstep.
- At the hospital daycare, one of the child-care workers suggests to Peter Benton that he may want to have baby Reece's hearing checked. Doug Ross dodges a bullet by admitting upfront his error in detoxifying a baby without permission. Having been acting Chief for over 6 months, Kerry Weaver puts her name forward to replace David Morgenstern as Chief of Emergency Medicine only to be told she will have to compete for the job. The doctors treat a couple of Elvis impersonators who sky dive into Lake Michigan. When drugs go missing from the ER, John Carter suspects Anna Del Amico's ex-boyfriend.
- On a busy Halloween night, Carter and Abby are the only staffers in costume when victims of an apartment building fire pack the ER. Corday takes on a new med student for a surgical rotation - Paul Nathan, who suffers from Parkinson's disease and decided to pursue medicine after being diagnosed. Despite a difficult first day, both professionally and medically, Nathan makes a difficult diagnosis. Romano's rehab lags behind his expectations, and he begins to think his role in surgery is no longer an option. In a moment of personal weakness, he tries to express his feelings for Corday. Weaver continues to display erratic behavior, raising staff suspicions about her menopause. Luka's burgeoning sex addiction worsens, as an affair with Chuny is revealed, and tensions rise when he treats a patient with a perpetual erection.
- Kovac reacts negatively when he sees Abby giving extra attention to a patient; Ray and Gates clash over a patient, pinning Neela in the middle; and Ben takes things to the next level with Sam. Meanwhile, Pratt is under investigation and Weaver says a final goodbye to the ER.
- An heir to a plastics fortune is kidnapped. There are pools of blood at the crime scene. Was it from the victim or one of the kidnappers? Either way, the development complicates Erskine's investigation.
- Dr. Pratt brings a gun into the ER; Dr. Weaver tries to conceal her pregnancy; a woman plots against her dying husband; Dr. Chen treats math students who overdosed on an unknown stimulant.
- An elderly man is brought into the ER after being mugged, and sees things as if it were the 1960s.
- Mark has to deal with the fact he can't see Rachel during the holidays and takes care of a Holocaust survivor whose grandchild is missing.
- A Native American, Joe Cloud, who served under Erskine during the Korean War, kills a man who was trying to rape his wife. Cloud flees custody and Erskine attempts to bring him in while trying to keep Cloud from harm.
- Erskine and Daniels investigate a St. Louis trucking company. The Organization uses trucks from the company to hijack shipments from other trucking firms. The Organization also takes a cut of the profits of the St. Louis company, which gains more and more business as its competitors are driven out of business. The owner of the St. Louis company begins to crack under the pressure and seeks a meeting with Erskine -- a meeting the Organization will seek to stop.
- Lt. Frank Harris, a tough plainclothes police officer, questions Joseph Spooner, a junkie informant, to try to break a case. After Harris drops Spooner off, he is beaten and killed by two hoods. Harris was the last person to see Spooner alive and the junkie's death sets off protests about police brutality. Erskine and Rhodes are called in to investigate before a volatile situation turns explosive.
- An injured and condemned murderer wants to die in the ER rather than await execution; Abby advises a neighbor to seek shelter from her abusive husband.
- Dr. Weaver is in a difficult situation when an alderman tests positive for syphilis. Dr. Carter is impressed when he meets a man who runs an inner city clinic.
- In Portland, a city commissioner who was actively involved in the fight against organized crime nearly dies in a murder attempt. The hitman is also injured and flees to California. Crossing a state line brings the FBI into the case and the bureau's investigation is supervised by Erskine and Colby. The hitman ends up in San Francisco, where he and a young pregnant woman fall in love. The FBI foils a second murder attempt on the commissioner. Now, the first hitman is marked for murder for failing to kill the commissioner. and his girlfriend is also endangered.
- Mark has to work for the fourth night in a row while a lot of the staff are absent and the number of patients is towering.
- Greene confronts Corday when she orders Rachel out of their home; Abby tries to protect a battered neighbor who refuses to press charges against her husband.
- An Eastern Bloc nation seeks to prevent the defection of Gerald Salzman, one of its key officials, to the U.S. Salzman's wife has already flown to the U.S. with forged papers. Sylvia Prince, who acts as a messenger and coordinator of espionage operations, has activated a sleeper agent who supposedly defected to the U.S. six years earlier. The plot of the conspirators is to kidnap Mrs. Salzman to force him to go back to his homeland. The FBI is on the case after a U.S. State Department official, who knows Salzman, is murdered. Erskine and Colby race to rescue Mrs. Salzman to ensure Salzman's defection takes place.
- The police question Drs. Pratt and Gallant about a rampage at the diner across from the ER. Dr. Lewis befriends her teen admirer, a cancer patient.
- As the new director of diversity, Benton studies medical school applications and discovers that his own academic record did not qualify him--he was admitted because of affirmative action. Weaver feels uncomfortable amongst Legaspi's lesbian friends. Carter treats an unvaccinated child who contracted measles.
- A chance encounter on the street leads Chet to try out, and eventually to get hired, for a job playing an athletic coach in a breakfast cereal television commercial. Chet discovers, however, that shooting 30 seconds of film isn't as simple as it appears when the final product is seen on television.
- Carter greets the returning Kem, but their meeting with his father, Jack, gets tense after Carter announces plans for his grandmother's estate.
- Two boys brought in after a fight at school leads Cleo to discover that one of them has a number of bruises and infected wounds. Hathaway's obstetrics nurse, Abby Lockhart, joins the ER as a third year medical student on an ER rotation.
- Two deaths, 3,000 miles apart, put Erskine and Colby on the trail of Cosa Nostra boss John Duquesne. The first fatality occurred a decade earlier and the body was discovered during a routine military exercise near San Jose. The other is the killing a retired hitman on the other side of the U.S. The Cosa Nostra decides that Duquesne needs to get rid of his ex-wife, who could implicate him in the earlier killing. The FBI tries to connect the two murders and prevent a third.
- A woman who broke her leg while trying to escape a house fire is brought in with her husband. The husband, Mr. Lotery did not let the paramedics to check him over. Then his brother-in-law arrives, saying that he predicted that something like the house fire would happen - it was actually an arson. Mr. Lotery's brother-in-law becomes aggressive and accuses him of being a pervert, specifically a pedophile. Mr. Lotery denies the accusations. He was sued but found not guilty. When Mr. Lotery is waiting for his wife who's in line for X-ray, he has the chance to calm down a young girl who is afraid of needles. When his brother-in-law sees this, he brutally assaults him, while Dr. Brenner calmly watches nearby... Meanwhile, Neela gets sued for malpractice.
- Pratt and Weaver try to create a Christmas miracle when they work to save a girl wounded from gunfire. Eve gets into trouble after punching a disruptive patient. Also, Abby has a special gift for Luka.
- Carter and Lucy are discovered and the staff struggles to save them and go on with normal patient care.
- In California, a gang has stolen weapons from the U.S. military. Erskine and Rhodes are assigned to capture the gang.
- A soccer mom finds herself completely aware of everything going on around her, but is unable to move or speak after suffering a stroke.
- A young Greek stops at nothing to secure a passage to America.
- Curtis Ames, a carpenter who suffered a stroke under Kovac's care, sues him for malpractice. Kovac and Ames square off in court as each man's recollections of Ames' treatment are recounted via testimony and flashbacks. Meanwhile, Abby returns to work and must adjust to the dramatic changes in her life, and Pratt's early morning trip to the barbershop results in a new awareness of community need. Also, Abby and Pratt try an unconventional method for treating a heart patient and Neela tries a risky procedure which doesn't sit well with her chief.
- A young man drives to FBI headquarters from Virginia. He is carrying a large amount of cash and has been shot. He also can't remember his own identity. Is he a criminal or an innocent. The title stems from the story of blind men trying to establish what an elephant looks like by feeling different parts of the animal. That story summarizes the challenge facing Erskine and Rhodes as they try to reconstruct what happened. On top of that, a pair of hit men are stalking the boy.
- A prisoner at a federal prison in Colorado is killed. Dying, he tells the warden that a break-out is about to be attempted. Because the prison houses some of the worst criminals in U.S. custody, the FBI is called into the case. Erskine goes undercover as a prisoner and is the new cell mate of Fritz Moline, a cunning criminal suspected of organizing the escape. But Moline, after planning the escape for five years, may kill Erskine first.
- Doug treats dying Chia-Chia. Mark however feels he's not doing the right thing for Chia-Chia.
- As Carter prepares to open a new facility for the underprivileged, some old friends/colleagues gather. Rachel Greene, Mark Greene's daughter, applies for an internship at County.
- CNN anchor, journalist, and heart-throb for many women: Anderson Cooper. Katy Perry also performs from her widely popular new CD.
- Doug Ross' hopes of renewing his relationship with Carol Hathaway take a positive turn after the two of them kiss following a particularly stressful trauma, but his hopes are dashed when she decides to move in with boyfriend Tag. John Carter has a particularly good day when Dr. Green successfully walks him through a complex procedure. Haleh takes Dr. Benton to task when he refuses to act as a role model for a young gangbanger she has an interest in. Benton is also competing with Dr. Langworthy for a prestigious fellowship. It's Susan Lewis' birthday and her sister Chloe shows up at the ER drunk.
- The ER is on guard as Gates gathers the new interns to treat a terrorist, but it's the new doctor and her tough disposition that has everyone on the defensive.