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- An old friend of Thackery's, Abbie Alford, arrives at the hospital seeking his help. She has lost most of her nose as the result of syphilis, which she acquired from her now absent husband. Thackery agrees to perform a skin graft. Drs. Gallinger and Chickering try to learn the surgical process Edwards offered to show them but are unable to do so. Dr. Edwards is looking to open a treatment center in his basement office during night hours to treat black patients. He has to face the realities of what he can accomplish with limited resources however. Herman Barrow faces an ultimatum from his loan shark who seems to be quite ready to exact payment from him, one way or another. Ambulance driver Tom Cleary is surprised to see someone he knows enter a rundown tenement building. Other cases of typhoid fever begin to appear.
- Already fuming over the hospital's faulty new electrical system, Thackery tasks Herman Barrow, The Knick's crooked superintendent, to deliver more cadavers so he and his team can test out novel surgical procedures. With more patients dying, Algernon offers to share a procedure he learned in France, but is rebuffed by Thackery and Everett. Cornelia addresses a typhoid-fever outbreak; Lucy is taken into Thackery's confidence; Sister Harriet breaks a taboo. Algernon finds an alternative way to perform his duties.
- Dr Thackery is Chief Of Medicine in a 1900 New York hospital, The Kickerbocker, battling a cocaine addiction, high mortality rates and bureaucratic corruption to save lives in a world before antibiotics and blood transfusions.
- After a deadly virus wipes out humanity, Phil Miller searches the country for more survivors.
- The return of a kids' TV show from the 1980's coincides with the disappearance of a young child.