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1-24 of 24
- Alex must become the unlikely advocate for a violent young prisoner brought in to Hope Zion Hospital, while Joel connects with a disfigured refugee and tries to convince Dr. Dana Kinney to come back to operate on him. Meanwhile, a spirit who is familiar to many Hope Zion doctors shows up in the morgue when Charlie is about to do a routine procedure.
- After a young, healthy, and hunky fireman dies suddenly at a Hope Zion Hospital fundraiser, Alex must take the stand at Hope Zion's Morbidity and Mortality (M&M) Rounds to find out what went wrong and who is to blame. Meanwhile, Charlie and Zack deal with a nervous aspiring nun with an ankle fracture that turns serious when they stumble upon a potentially fatal allergy. A busy Joel struggles to balance his workload as Chief with his growing commitment to Sonja, and must decide if he's ready to step up to the plate.
- When a heat wave hits the city, Alex is appointed Trauma Team Leader as the hospital is faced with an influx of patients during a blackout. With no back-up power available, Dawn and Charlie must figure out a way to continue their surgery as Joel and Maggie attempt to keep a patient alive while stuck in an elevator.
- When Alex and Joel end up stranded in the middle of nowhere with a severely injured couple, they're forced to use only what's around them to stabilize the pair until paramedics arrive. Meanwhile, back at Hope Zion Hospital, Charlie must try to save the wounded leg of his former college roommate as Gavin attempts to help Shahir improve his bedside manner.
- When Alex is forced to put a patient's gender reassignment surgery on hold, she discovers a secret in his medical history that could save his surgery, but tear his life apart. Charlie deals with a patient who is healthy, sane - and convinced she is going to die at midnight. Meanwhile, Joel secretly helps Sonja deal with a patient of hers who's been admitted to Hope Zion Hospital.
- Alex is awake but still not back to her old self, and Dawn has given strict orders for her recovery plan. Meanwhile, Charlie and Joel square-off over differing treatment options when two fused-together burn victims are brought into the ER. Maggie finds herself in a whirlwind of emotions triggered from the fallout of her miscarriage.
- When Alex's brother Luke is admitted to Hope Zion Hospital in critical condition, Joel and Charlie must work together to keep him alive while keeping his admittance a secret from Alex. Meanwhile, Alex figures out a way to remove a tumour from a patient pregnant with twins, while Maggie is thrown off her game by the patient's gorgeous OB/GYN.
- While the BAU looks for a vigilante killer on the loose in Cleveland, Rossi is concerned when his former Marine sergeant goes missing and heads to Los Angeles to find him. Also, the secret JJ has been keeping from the team may be catching up with her.
- The BAU travels to Milwaukee when multiple murder victims are found in shallow graves, with no apparent cause of death.
- Dawn diagnoses Alex with an irregular heartbeat. The Great Randall returns to Hope Zion Hospital after an experimental cancer treatment goes wrong. Meanwhile, Charlie struggles with the implications of his fight with Joel, who is trying to treat a troubled mathematician. One of Hope Zion's staff is attacked and their life is left hanging in the balance.
- When 3 unrelated people, of different ages and gender, are kidnapped the BAU races to find the connection and find them before the Unsub kills them.
- The BAU must track down a killer who sends their victims a warning before poisoning them with arsenic, without ever seeming to come in contact with them.
- The team investigates a serial murder case in Bakersfield, California.
- The team heads to Seattle to hunt for a murderer whose MO appears to change at random.
- Atlanta PD has invited the BAU in for an equivocal death investigation, that of investigative journalist Albert Stillman, who died being run over late one evening as he wandered into highway traffic. An eyewitness who tried to help Stillman just before he was run over states that he was waving his arms in the air yelling, "get them off me", this depiction which goes against Stillman's history of no mental illness. Reluctantly, Stillman's editor, John Carlson, discloses that Stillman was using heroin as medication for a back problem. Stillman was scheduled to meet with a source on a story concerning vaccinations when he vanished for three days just before he died. Garcia learns that another person associated with the case is a Dr. William Suri, a research scientist of entomology, who is later found dead, shot to death. Upon investigation, the team discovers that both Stillman and Suri were abducted - meaning that they are dealing with a serial killer - and had minute bite and deep self-inflicted scratch marks. They thus come to the conclusion that the unsub has delusional parasitosis - the belief that he is infested with bugs - and is looking for people to support his delusion by making them feel what he feels. When they don't support the delusion, he kills them. Based on that theory, the team believes his next victim will be someone in that vein, someone who may have a similar delusion. Locating such people may be easier than getting them to cooperate in the investigation, even if there is the threat of what happened to Stillman and Suri happening to them.
- A terrorist hacks a passenger's tablet and uses it to take control of the auto pilot of a plane in order to crash it.
- On October 30, 2014, a frightened eleven year old Joshua Parker is found at a Halloween fair in San Diego. He went missing on Halloween day the previous year. His case mimics that of Tommy Wilcox, who went missing on Halloween 2012 in Los Angeles, only to be found on Venice Beach October 30, 2013, alive but he who eventually died of malnutrition a few hours later. Joshua, however, is expected to live. Both boys had atrophied muscles, and had splinters and puncture wounds, although Joshua seems to have been fed somewhat properly. Both boys were also considered troubled, Joshua who was never listed officially as missing since he was a chronic runaway. The problem for the BAU is that Tommy's captor, Rodney Tanner, who confessed to the crime, is currently incarcerated, meaning that he either had a partner, there is a copycat loose, or that his confession is a lie. They have to figure out this issue before another troubled early or pre-teen Caucasian boy is abducted in the next day. Reid comes to the conclusion that the boys were housed in a homemade wooden box, which accounts for all their physical issues. Discovering a case similar from the past of boys so confined, especially as it relates to Halloween, may provide clues as to the identity of the unsub.
- Rossi encounters an avid follower with an important secret, and a physically and psychologically damaged woman lets loose with personal murders.
- News of Alex's pregnancy and the mystery of who the father is circles the hospital. Joel returns after his quick incarceration. Maggie studies for the board exam and deals with a patient who has a fear of doctors. Meanwhile, Alex and Dawn continue to deal with their patients in need of a heart donor.
- The BAU is called to Salt Lake City, Utah to investigate a suspicious triple-homicide. Throughout the course of their investigation, they eventually discover that a fugitive killer could possibly be linked to the UnSub and he could also be a familiar face.
- The BAU heads to Indianapolis, Indiana where a bomb has just exploded at a popular chain coffee house, killing several. The police believe this bomb, crudely made using TNT, is related to a bombing one week earlier at a school, also using TNT. That bomb, because it was detonated at night, killed only one, the night time custodian, who was not supposed to be in the school at the time. Based on the exact location of the coffee shop bomb, Rossi and Morgan are uncertain if the bomb was meant to be as deadly as it was or not. In relative terms, there were also some good news stories associated, where a pregnant woman was saved, she who delivered a healthy baby. A third bomb attempt coupled with other information leads to the team figuring out who the bomber is. However, that third bomb, plus the school bomb, provide the biggest clues as to the nature of the entire picture. They hope that planting a little public misinformation may help them catch the unsub.
- When an innocent family of four is abducted while vacationing in Barbados, Hotch and Cruz enlist the assistance of the FBI's most elite team in handling international cases. They realize that this situation closely resembles a case that the BAU once handled in Florida. Upon this discovery, the BAU contacts Jack Garrett, (Gary Sinise) the unit chief of the team with whom they will be working. The BAU will need to pool together their skills with Garrett's elite team in hopes to save this family. This will serve as the backdoor-pilot episode for the new spin-off, Criminal Minds: Beyond Borders.
- When a family from Maryland is found murdered at their dining room table, the team tracks down other family members and friends to uncover secrets and details from the past in hopes to find out what may have led to it, and to catch who is responsible. Also, Hotch must try to make peace with his father-in-law, Roy, (Ed Asner) after discovering he's been diagnosed with Alzheimer's, and it has become painfully noticeable.
- The team heads to Los Angeles, California where three people have been murdered in two separate incidents over three days, each victim shot thirteen times while sitting in a car or next to a car located in the same crime ridden neighborhood. The ballistics show the same .45 caliber gun was used in both instances. The first victim, Gary Fisher, was known to have frequented prostitutes and was found in area where he was probably meeting with one. Nate Cochran and Tasha Brooks, the second and third victims in the same car, were a john and a hooker. When a fourth and fifth victim are discovered together, they an elderly woman, Clara Miller, and who seems to be a mugger, Lamar Taylor, the team believes the unsub is a vigilante - a moral enforcer - who is looking to clean up the streets of what he sees as immoral behavior. Because of the overkill, they know the reasons for the murders are personal. Information they learn about Clara and Lamar, and the discovery of subsequent victims leads to the team believing the unsub is devolving into believing everyone is a criminal. As such, they have to put together the pieces quickly to find him before more innocent people are indiscriminately killed.