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- The doctors of Chastain are surrounded by new rules and doctors, as Red Rock Mountain Medical takes over the hospital; Conrad finds himself in a dangerous situation when the construction for a neurosurgery center causes a gas explosion.
- In an effort to save Chastain, Bell considers selling the hospital to a conglomerate, but Kit tries to make him see that the negatives will outweigh the positives. With Conrad's help, Nic tracks down Kyle and pleads for him to reconsider donating a kidney to Jessie. Meanwhile, Mina voices her concern to Austin when Shira is assigned to Micah's surgery and Devon fights for the care of a patient whom the doctors suspect is uninsured.
- Simone and Alex prepare to compete against newcomer Amber for their ASA performance. Noah's father, Bobby, returns to help Noah with his sobriety and fatherhood. Meanwhile, Miss Christine, Cousin Duke and Cousin Rashad come to town, much to the chagrin of Carlotta and Cassie. Then, Leon makes Cotton an offer.
- To campaign for the ASA Awards, Gravity throws an Easter brunch showcasing their artists, but as the awards draw nearer, the future of Take 3 and their solo careers are on the line. As the label faces possible bankruptcy, Carlotta must rally the troops to woo Empire executive, Giselle, in hopes she will invest. Star struggles to juggle Davis and her career, and clashes with Noah's mom, Dianne. Meanwhile, Alex plans for her future and Simone doubles down on her activism, which puts Angel in danger.
- Everyone is on edge, but the girls must stay focused on the events leading up to the ASAs. Star and Noah struggle with parenthood while being in the spotlight, as Alex deals with her father's retaliation for her refusing his "gifts." Meanwhile, Cassie continues to manage Rashad's music career and Carlotta makes a shocking discovery that will change the lives of many.
- The ASAs finally arrive and Take 3 fights Amber Drake for the top spot. Alex prepares for her wedding, but someone from her past returns to wreak havoc on her big day. Meanwhile, Star finally makes a decision about Davis, Carlotta continues to mend things with Rashad and the season ends with a bang.
- When a police officer brings in an injured criminal, the staff must keep him alive; Nic gets roped into a surgical rotation with Cain that leaves her questioning the way he operates; Conrad makes a shocking discovery about the hospital.
- Intending to garner publicity for the hospital, Cain tries to recruit Bell and Kit on a dangerous surgery; the Raptor develops an emotional attachment to a patient; Mina's friend arrives with shocking news.
- After a plane crashes in Atlanta, Devon is overcome by guilt at the thought that he could have prevented the tragedy. Bell, who was a passenger on the plane, makes it his personal mission to save the life of the man seated next to him. Meanwhile, Adaku returns to ask Mina a big favor, the Raptor struggles with telling his adoptive parents about meeting his biological father and Conrad and Nic consider risking it all to investigate a drug that might be linked to Jessie's death.
- Conrad doubts Devon's judgement when a patient who was pronounced dead suddenly revives; Cain and Nic butt heads over the care of a white supremacist; The Raptor and Mina uncover new information about Red Rock Medical.
- On National Nurses' Day, Chastain's nurses are severely understaffed and overworked, leaving them all feeling exhausted and underappreciated. Cain performs a dangerous surgery on a new patient he won in a game of poker. Meanwhile, Conrad discovers that his father has been administered the same drug that he fears played a role in Jessie's death, The Raptor comes face-to-face with his birth mother for the first time and Irving attempts to take the next step in his relationship with Jessica.
- Cookie confronts Damon about why he lied to her; Andre is forced to deal with an unforeseen family complication; Becky and Giselle try to get the star power they need from their first Bossy Media artist; Tiana helps Devon find his sound.
- Lucious' plan to escape finally comes to a head; Cookie finds herself in a dangerous situation with Damon; Andre is haunted by a ghost from his past that he can't seem to shake; Tiana receives backlash over a social media post.
- A happy family occasion brings the Lyons back together but no one is able to agree on anything; Lucious comes face-to-face with demons from his past; Cookie reaches a breaking point; Andre encourages Tiana to smooth things over.
- Conrad comes under fire when a former patient files a malpractice lawsuit against him, putting Bell in a difficult position with Red Rock. When Devon discovers that his VIP patient has a life-threatening brain condition, the doctors ban together to perform a risky surgery. Meanwhile, Mina discovers that Adaku has a dangerous heart condition that puts her and the baby at risk, and Kyle forms a personal relationship with a patient.
- When one of Chastain's own is brought into the emergency room with life-threatening injuries, the staff rallies around each other to try to save her life, while disagreements over how to best handle her care put Cain at odds with the rest of the doctors. Also, Bell is met with an unexpected response when he voices concerns regarding the nursing shortage that Nic brought to his attention. Meanwhile, Conrad turns heads when he shares data about Hemopleatin, and Kyle begins volunteering at the hospital.
- Lucious tries to make amends for his wrongdoings with an old friend; Cookie vies to take control of the house; Andre and Lucious go head-to-head in a competition to figure out the direction Empire should be heading in.
- Upon dubbing Thanksgiving "the most dangerous day of the year," Devon and Irving are inundated with patients in the ER. When an A-list celebrity enters the hospital after swallowing a wish bone, Logan Kim assigns a new surgeon to the case in the hopes of garnering extra publicity. Meanwhile, tensions run high at the Raptor home when he hosts his biological and adoptive families for a Thanksgiving dinner and Kyle interrupts Nic and Conrad's low-key plans.
- On Devon's last day as an intern, he and Conrad are faced with a moral dilemma over a suicidal patient who is in need of a liver transplant. When Bell discovers that Cain is keeping braindead patients alive in order to boost his survival rates and add to Red Rock's profits, he decides to take matters into his own hands. Meanwhile, Adaku goes into early labor, causing a strain on her heart and Mina is left in doubt over how to best handle her care.
- After being terminated from Chastain, Conrad has difficulty figuring out his next step and distracts himself by accompanying a patient on a zero-gravity adventure. In his first move as the new Chief of Surgery, Cain puts the doctors on a commission-based pay system, which causes Devon's new intern to agree to a procedure before weighing the risks. Meanwhile, Mina struggles with taking care of Adaku's baby and Bell's supplement company gets its big break.
- While working at their non-profit clinic three hours outside of Atlanta, Nic and Mina treat a patient with a failing heart VAD, forcing them to find a new battery in time to save her life. Conrad gets a call from a previous patient in crisis after being sued by Red Rock for medical expenses he can't afford. Meanwhile, Devon's VIP patient, Nadine, returns to the ER and Cain tries to get close to Bell's business partner from the supplement company.
- Cain feels disrespected by Logan Kim when he is left out of a major decision regarding Conrad. Meanwhile, the doctors work together to try to save the lives of two big Red Rock donors who were involved in a jet skiing accident. Then, Irving and Devon realize that three of their patients, all with different symptoms, could actually be triggered by the same thing. Also, Bell's supplement company proves to be more lucrative than anyone anticipated, but an unexpected snag could put it in jeopardy.
- The new neurosurgery center opens, and Nic is forced to work alongside Cain again; a heart transplant has an unexpected result; Bell asks Conrad to reexamine three patients who may have been poisoned.
- When Nadine's father comes to town for her birthday, Devon enlists the help of the whole staff, as well as one of his patients, to ensure that he makes the best first impression. Red Rock decides to cut the entire OBGYN department and Logan Kim leaves Conrad with the difficult task of letting the residents go. Meanwhile, Nic cares for a teenage patient whose condition is deteriorating.
- A renowned pediatric surgeon is called over to Chastain for an extremely difficult surgery on a newborn, but when she arrives, The Raptor and Devon realize she is not fit for surgery, resulting in a situation more complicated than they could have imagined. Meanwhile, a Dolly Parton drag queen is admitted to the ER after collapsing on stage, leading Bell and Ezra to a potentially life-saving discovery. Also, Nic and Conrad suspect their patient may be the victim of sex trafficking and Nadine delivers some surprising news to Devon.
- Conrad finds himself caught between his duties as a doctor and his loyalty to Kitt, when he discovers that her son-in-law may be suffering from a serious disease. While moonlighting at a long-term care facility, Devon and Nic make a shocking discovery about a former patient who fell victim to Cain's manipulative practices. Meanwhile, after jumping into a new opportunity as a TV doctor, Bell is left without any surgeries and The Raptor brings him in to help on an important case.
- When Cain becomes aware of an emergency situation breaking out at the hospital, he recruits Ezra to help keep it under wraps. Also, Nic works to come up with a support system for a patient in need of a lung transplant. Meanwhile, Kitt's son-in-law's condition continues to worsen.
- Just when Derek's condition seems to be improving, a severe complication arises, causing Kitt to fear that he may be the latest victim of Cain's cover-up. When Cain's former girlfriend is admitted to the hospital for surgery, the doctors finally get a glimpse into his personal life. Meanwhile, Conrad fills in Marshall on the emergency situation facing the hospital and Mina and The Raptor work on saving the heart of a salsa dancer.
- The 126 arrive at a funeral where another dead body has crashed the burial, and then to a hospital where an MRI has gone haywire. Owen and Tommy each feel displaced in their homes. T.K. makes waves in his new position.
- The first responders deal with a man trapped in a present, a mistletoe stunt gone awry and a Christmas-light showdown; Bobby contemplates his future with Athena.
- Murtaugh and Cole investigate after a robbery of a truck filled with fine art. Cole deals with lingering feelings for Natalie after a development in her life. Meanwhile, Riana blackmails Murtaugh into letting her go to a concert after she catches him in a lie he told Trish.
- Murtaugh turns to Cole's former mentor, Tom Barnes, for help on a high-stakes cartel case. Meanwhile, Murtaugh and Trish meet Natalie and Maya for the first time, and tensions mount between Bailey and "The Gute", as the new partners begin to work together.
- Cole confronts his past when his former mentor, Tom Barnes, delivers alarming news, as he and Murtaugh investigate a robbery of safe deposit boxes. Meanwhile, Murtaugh clashes with Trish's new client, Louie Gutierrez aka "The Gute" and enlists Bailey's help to investigate.
- Cole needs to talk to Natalie about their relationship. Murtaugh makes an unlikely friend.
- While Cole gets into the holiday spirit for his first Christmas with Maya, Murtaugh hopes he can convince RJ to come back home from Costa Rica for the holidays. At the precinct, Cole and Murtaugh are saddled with a complicated burglary and home invasion case. Meanwhile, Avery's holidays are a bit blue, and Bailey is still trying to figure out her new partner.
- When Cole and Murtaugh investigate a case involving a father and daughter (illegally) crossing the Mexican border, they end up uncovering a major issue with California Boarder Patrol. Meanwhile, Trish prepares her campaign for D.A. and must face parts of her past, before they find their way into the media spotlight. Cole also confronts his past when he experiences flashbacks as a result of an injury.
- On the precipice of Gotham's reunification, Gordon and Bruce find themselves face-to-face with a newly transformed Eduardo, and discover the real mastermind behind the city's current chaos. Meanwhile, a pregnant Barbara turns to Lee for help.
- With the nation divided more than ever, Evangeline proposes a country-wide meeting to revive the Mutant Underground.
- Carlotta goes missing, suspicions about Olivia rise as she continues to pursue a friendship with Alex to cope with the loss of her sister. Maurice and Mateo settle on an agreement that tests Noah's loyalty. Miss Bruce and Bobby connect over their similar pasts and Noah, Simone, and Star try to keep Carlotta's Music Festival afloat in her absence.
- In an effort to boost ticket sales, Mateo brings on controversial rapper Lil Dini, who clashes with Take 3. Star and Noah confide in each other about their relationship issues and Simone is put in a sticky situation when Jackson is cast as her co-star in a movie. Meanwhile, Derek's keeping a secret, Cotton's suspicions about Cassie grow and Xander pushes Cassie to find the rat in her organization.
- Gravity Media recruits social media influencer Chloe David to attract more attention to Carlotta's festival, but Take 3's plan to hijack attention to their album doesn't go as planned. Cassie's relationship with Xander gets more complicated and Star must face her fears in order to build her family with Jax. Meanwhile, Detective Montero puts Derek in a dangerous position that could cost him everything.
- Carlotta returns to Gravity Records, but finds out a lot has changed. Star meets Jackson's mother, Becky, and makes a shocking discovery. Meanwhile, Simone asks Nina for help when Angel returns in an unlikely way; Alex, still reeling from her fight with Derek, struggles with writing her own music; and Noah becomes dangerously paranoid and enlists his father, Bobby, as his new manager. Then, Cassie and Carlotta take steps towards making amends and Carlotta finds healing in confronting her father, Calvin.
- Carlotta does what she can to make the Rhythm and Bells Festival a success. However, challenges arise when Star ends up in a legal bind, Alex makes a major career move, Simone is hiding a secret and Cassie gets out of jail seeking revenge. Meanwhile, Derek and Ruby volunteer at the shelter, where Ruby comes face-to-face with the man who attacked her. Then, tempers flare as Carlotta and Cassie's father, Calvin, shows up unexpectedly.
- When Bell makes the executive call to utilize Julian Booth's medical devices, rather than the hospital's usual products, Kit and AJ must stop their momentary feuding in order to team up against him. Elsewhere in the hospital, Conrad and Nic work to make a child's dreams come true after finding out his cancer has returned and the rest of the staff takes notice of Julian and Devon's new friendship.
- Devon's doubts about his relationship reach a peak as his friends and family gather for his big wedding day. As Chastain's leading medical device company, Quovadis, continues to succeed, Julian makes a discovery that leaves her uneasy about her involvement in it all. Meanwhile, Conrad continues to work on his relationship with Marshall and Bell takes a risky offer in order to make a mistake from his past disappear.
- Lane Hunter's victims and their families become outraged when she is released from prison. Bell, although responsible for posting Lane's bail and getting her released, continues to be tortured by her manipulation.
- When a medical device fails on a former Chastain employee, an investigation is opened up, which pits Dr. AJ Austin against Quovadis. As Mina and Bell work to get to the bottom of what went wrong, Devon distracts himself with another patient who's experiencing mysterious stomach pains. Meanwhile, Nic forms a bond with her new partner at the clinic and Conrad's relationship with the Barnett family continues to grow.
- When a nasty flu season turns out to be masking a terribly infectious disease, Chastain must race to quarantine and diagnose infected patients. While Conrad, Nic and Alec work tirelessly on Meg, who was Nic's favorite guard from her stint in prison, Devon and the others treat Sam, a love-sick patient with flu-like symptoms. Mina finds herself testing Quovadis medical devices in an effort to defend Dr. AJ Austin, who, feeling responsible for the death of a patient, is serving penance by staying away from the OR. Meanwhile, Conrad is prepared to take the next step with Nic, but finds that she may not be as ready.
- Conrad, Kitt, Mina and the Raptor work to save the life of a med student in need of a triple-organ transplant, drawing Bell back to the OR for one of the Chastain's riskiest surgeries yet. After the police find Julian's empty car in a nearby lake, Devon does some investigating of his own to find out what might have happened. Meanwhile, Mina and the Raptor hound Bell to halt his business with the risky medical device company, Quovadis, and Nic makes a rash decision regarding her sister.
- When Conrad's attempt to surprise Nic with a lavish Valentine's Day dinner is foiled, he gives the reservation away to someone who could really use it. Mina and Devon distract themselves from all Valentine's celebrations by trying to figure out how their seemingly healthy neighbor has suddenly passed away. Meanwhile, Kitt gives dating advice to a sex-injured patient, Irving hits a crossroads in his not-so-secret relationship with Nurse Jessica, and Bell decides to celebrate the day in the OR.