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- A profile of Owen Suskind, an autistic young man who learned to communicate with the help of animated movies and was the focus of the documentary Life, Animated (2016).
- One year after the tragedy in Uvalde, Texas, "20/20" follows the community's journey through horror and healing;
- This is mostly focused on the big Christmas hype for Super Mario Bros 2 and the Legend of Zelda 2 and how scarce these two games are due to the "chip shortage" of the time.
- A look back at the lives and careers of actresses -- and mother and daughter -- Debbie Reynolds and Carrie Fisher.
- Entertainers and legends, who passed away in 2016, are profiled, including Prince, Muhammad Ali, Florence Henderson, Fidel Castro, David Bowie, Glenn Frey, Merle Haggard, Pat Summitt, Arnold Palmer, Craig Sager, Gene Wilder, Doris Roberts and others.
- The brother of Idaho mom Lori Vallow, who faces charges in connection to the murders of her children, opens up about tragic family events;
- 1978– Unrated8.6 (23)TV Episode"Virginity Restored" examines a plastic surgery that can restore a woman's hymen. "Johnny Depp: The Ultimate Outsider" profiles the popular actor known for his quirky movies. "Unprepared for Terrorism" examines how fire fighters, police, EMTs, and other first-responders are ill-equipped to deal with a possible terrorist attack. "Give Me a Break" looks at how some people are being fined for putting up signs.
- Thirty years after she had learned that she was switched at birth, Kimberly Mays reveals the details about her tough childhood and her struggle with her identity; interviews with Kimberly's biological siblings, and her mother, Regina Twigg;
- 1978– 1h 21mUnrated8.6 (105)TV EpisodeChildren from the Turpin family, who were held captive in their California home, discuss how they endured harrowing conditions, including starvation and violence, and reveal details about their rescue.
- When a husband is violently murdered, his wife and her alleged lover become suspects;
- A serial killer's family member reveals shocking secrets that he kept to get away with murder;
- A world renowned matchmaker helps a Bronx school teacher find love and complete her family.
- New details about the 2010 murders of Sam Herr and college student/dancer Juri "Julie" Kibuishi, including David Wozniak's confession, his motive, and fate as he sits on death row;
- Interviews with Amanda Berry, Gina DeJesus, and Michelle Knight, who made headlines when they escaped their Cleveland kidnapper's home, after a decade of captivity;
- New interviews reveal shocking info on a botched murder investigation;
- A young anchorwoman, Jodi Huisentruit, vanishes from her home; the answer could be buried in a freezer.
- A man is imprisoned for his wife's murder, but he may not have been the one who committed the crime;
- Exclusive interview with a fake doctor, Dean Faiello, who hid a deadly secret.
- 20/20 offers a special report on the growing heroin crisis in America. David Muir goes to New Hampshire which has one of the highest rates of overdose death in the country. He also profiles several families that are dealing with effects of addiction and rehabilitation.
- John Quinones uncovers information reigniting a 20-year-old unsolved murder case;
- Barbara Walters profiles 3 little girls who have Progeria, a genetic condition that causes them to age at 10 times the normal rate.
- Brittanee Drexel's disappearance from Myrtle Beach, South Carolina, in April 2009 left her family and the nation struggling for answers about what happened to the missing high school junior.
- Police launched a 38-day nationwide search, after a teacher takes his 15-year-old student away with him;
- Late September 2014, Davison, Genesee County, Michigan: Christina Harris (Christina Ann-Thompson Harris) age 36 was found dead in her home. The police investigation went cold for several years until the Genesee County Medical Examiner changed her manner of death from "accident" to "homicide." In 2017, her husband Jason Harris, now age 47, was arrested for her murder and was found guilty by a jury. He was sentenced to life in prison with no chance of parole. It was determined that he had laced her morning cereal with an overdose of illegal heroin. This led to him being referred to as the "cereal killer."
- A college student is murdered after being stalked; questions are raised regarding whether the university failed to protect her;
- Kristin Smart, age 19, disappeared on Memorial Day Weekend 1996 from Cal Poly. For more than 25 years her family searched for answers and justice. Paul Flores was eventually convicted of her murder in 2023. Her body has never been found.
- Profiles of working individuals and families across America, who are struggling to stay in the middle class; issues of dwindling job opportunities, income inequality and community solutions are explained.
- 1978– 2hUnrated8.3 (15)TV EpisodeCrime novelist Scott Turow talks about the 1996 murder of Angie Dodge, which landed the wrong man in prison for 20 years;
- A mother spends time behind bars for her son's murder, until a "20/20" viewer helps crack the case;
- An interview with a Texas stepmother, whose picture perfect life masked a criminal past;
- When a mom is found dead in her luxury apartment, it isn't immediately clear whether it was a slip and fall or something more sinister happened;
- Performers Siegfried Fischbacher and Roy Horn open up about the infamous career-ending tiger incident that happened in 2003, their storied career, and the legacy of their Las Vegas residency.
- In 2017, University of Illinois scholar Yingying Zhang goes missing and a suspect's girlfriend works with the FBI to go under cover and secretly record a conversation that ultimately cracks the case;
- The life of disgraced mogul Lou Pearlman, including his role in one of the biggest Ponzi scheme in history, his blimp business, how he got involved in the boy band scene and how he led authorities on an international manhunt, which ended with his final destination to prison;
- 1978– Unrated8.2 (16)TV EpisodeTakeing viewers backstage for an intimate look at the making of a real high school musical. Over 100 students audition, but only 4 will win the chance to star in the performance.
- A twisted, fatal love triangle and the shocking truth on whether or not the stalker and victim are the same woman;
- A couple is murdered inside their home, possibly by someone trying to hide a secret double life;
- Video evidence leads police to learn the shocking identity of an Arkansas senator's killer;
- The investigation into the murder of a Texas husband and wife reveals that the killer may have been watching all along;
- YouTuber Ruby Franke's strict parenting facade crumbles when her son reaches out for help, unveiling secrets through body camera footage, calls, and her private journal.
- When a young couple is found dead, police learned that they were involved in an online feud and uncover a deadly catfishing scheme; "20/20" untangles the web of lies and unmasks the unlikely mastermind behind the murders;
- Ex-members of the Church of Scientology who crusade against it; actress Leah Remini discusses her fight against the Church of Scientology and her goal of making it lose its tax exemption status.
- An international investigation into Otto Warmbier's 17-month imprisonment in North Korea, and his death, which occurred less than a week after he was brought back to the United State in a state of unresponsive wakefulness.
- A woman, who acted as bait in a plan hatched by authorities to arrest her husband who was involved in a California kidnapping and torture case, shares her story; interviews with the kidnapper, himself, and a former prosecutor from his case;
- Decades after two barrels, containing the bodies of a woman and three children, were discovered in New Hampshire's Bear Brook State Park, a podcast renews interest in the cold case and helps lead to authorities solving it;
- In 2017, authorities reopen the investigation into the 1983 murder of Timothy Coggins, a young black man in Georgia, eventually charging two men, despite having no new DNA evidence to prompt the reopening;
- The family of murdered former NBA player Lorenzen Wright gets one step closer to justice, when his ex-wife pleads guilty to facilitating his murder --- nearly a decade after authorities had found his body in the woods;
- A look at the Boeing 737's controversial flight control software and how this software had mistakenly sent planes into deadly nosedives, including what Boeing knew about the concerns with that flight control system and when they had known about it;
- An investigation into the past of Lori Vallow, whom authorities had arrested in Hawaii following the disappearance of her two children, Tylee Ryan and Joshua "JJ" Vallow, charging her with desertion and nonsupport of dependent children, and concealing and destroying evidence.
- 1978– 2hUnrated8.1 (22)TV EpisodeFormer Silicon Valley star Elizabeth Holmes' trial and conviction for fraud, and the most recent developments in her life, including her relationship with a wealthy hotel heir and the birth of her first child; the upcoming trial of Sunny Balwani;
- An unprecedented case lands teen behind bars for encouraging boyfriend's suicide via text.
- 2015, Elmira, NY: A hockey player, Thomas Clayton, a brutal murder of Kelley Clayton, and a shocking witness --- the victim's young daughter.
- This installment discusses how Earl Olander's stolen family Bible held the clues in the case of the murdered Minnesota farmer.
- A twisted story of greed and murder, behind Chippendales;
- A love triangle, a murder and arson -- an exclusive prison interview by ABC News Correspondent John Quiñones with Nikki Entzel, the woman at the center of the crimes who still claims she is innocent in spite of the overwhelming evidence.
- When a woman who was abandoned as a newborn searches for clues about her biological family, she listens to several shocking confessions, has a family confrontation and finds two siblings who were also abandoned as infants.
- University of Virginia's former Associate Dean of Students Nicole Eramo talks about the Rolling Stone article, detailing the alleged gang rape of a University of Virginia student at a frat party.
- A jury finds a young woman, whose boyfriend committed suicide with her encouragement, guilty of involuntary manslaughter.
- Twenty-seven years after a Florida woman was fatally shot on the doorsteps of her home by an assailant in a clown costume, police arrest her husband's new wife.
- Exploring lingering questions about the mass shooting in Las Vegas, including the shifting timeline of the attack, the search for the gunman's motive, the missing hard drive, conspiracy theories. Also: interviews with those who knew the gunman.
- The extraordinary chain of events that led to a COVID 19 global health crisis; video diaries from inside China's quarantined cities and from passengers trapped on the Diamond Princess cruise ship, off San Francisco; reports from around the world;
- A prison interview with Nanette Packard, who is at the center of a deadly love triangle with wealthy businessman Bill McLaughlin and former NFL player Eric Naposki;
- The woman, at the center of a deadly love triangle, speaks out following a shocking confession;
- A Texas veterinarian is accused of murdering her military hero husband;
- A Facebook message holds the clue to the two horrific murders of both Scott Sessions and Heather Frank.
- 20/20 helps three people who are trying to reunited with their long lost families. It looks at the following cases: D.J. Williams who was abandoned as a baby near a Christmas nativity scene, Gina Lozada who is searching for a missing half-sibling, and Amanda Holdiness who is searching for her biological father.
- 20/20 goes to Georgia to examines the 2011 murder of Nique Leili whose husband Matt Leili worked in the security system business and installed an elaborate system in his own home. After footage from the night of Nique's disappearance is discovered to be missing, authorities build a case against her husband and eventually convict him of murder.
- Mark Carver, serving a life sentence for the 2008 murder of University of North Carolina student Ira Yarmolerko, speaks out.
- 1978– 1h 21mUnrated8.0 (19)TV EpisodeTodays theme is Truth and Lies: The Murder of Laci Peterson.
- Investigating a little-known study, headed by psychiatrist Dr. Viola Bernard, that saw several sets of twins and triplets separated as infants, adopted out to different parents and monitored to study the effects of nature vs. nurture.
- Anti-virus software titan John McAfee, whom Belize authorities names a 'person of interest' in a murder.
- A face-transplant recipient shares his story, opening up about his new lease on life, following his suicide attempt and surgery; included: his first meeting with his donor's mother, and an interview with the doctor who performed the surgery;
- A woman's infatuation with a married man, who didn't want to be a father, possibly motivated her to shoot her three young children, seriously injuring two and killing one;
- A wife and mother vanishes, without a trace, from her Utah home; featuring interviews with family, friends, and law enforcement;
- The search for a killer, whose reign of terror, over four days, left five Florida college students dead;
- Four decades after three Girl Scouts are murdered at summer camp, police attempt to crack the case.
- The latest on the investigation into the Idaho case, where four college students were murdered, including exclusive interviews and chilling new details;
- An inside look at an undercover investigation involving conspiracy, escorts, and murder-for-hire;
- On New Year's Eve in Benton Harbor, Michigan, Army Sergeant Kemia Hessel's husband is murdered. Police video shows a distraught Hessel, but investigators believe she arranged her spouse's death.
- Real-life designated survivors Dan Glickman and Gale Norton; actors Kiefer Sutherland and Kal Penn (Designated Survivor (2016)).
- New Hampshire teen Abby Hernandez talks about her 2013 abduction, captivity and abuse; also included is an interview with Lauren Munday, the woman who aided Hernandez's release;
- Todays star is Barbra Streisand.
- Todays star is Louis Farrakhan.
- After spending almost 10 years behind bars for his former girlfriend's death -- a crime he says he did not commit -- Nicholas McGuffin opens up, after his conviction is overturned;
- 1978– Unrated7.8 (13)TV EpisodeWhy the United States was unprepared for COVID-19, how officials failed and missed the warning signs, and what the country needs to do next to return to normalcy, after the COVID-19 pandemic has wreaked havoc on families, communities, and the economy.
- Notorious snitch Paul Skaink served as a witness in a total of 35 Florida cases, helping to send dozens to jail, including four to death row; the controversial use of jailhouse informants;
- A Diane Sawyer special report on the 1/2 million people living in poverty in Central Appalachia.
- DNA evidence links two former Stanford University employees to the 1973 murders of Arlis Perry, Leslie Perlov, and Janet Ann Taylor, featuring an interview with the family of one of the convicted killers;
- The mysterious disappearance of the first wife of an accomplished surgeon with a hidden dark side;
- Fugitive multimillionaire Robert Durst and the shocking trial that led to a murder conviction;
- Larry McNabney was a Sacramento, CA attorney whose body was found in a shallow grave in a vineyard near Linden, CA on Feb 5, 2002. His wife, Elisa McNabney and her friend, Sarah Dutra, were arrested for the murder of Larry McNabney.
- Two go on a safari, and one returns; an interview with a man who heard a shocking confession;
- Taking a look back at the Sherri Papini case and how she fooled investigators, family and the public with her phony fabricated kidnapping plot. Airing never-before-seen police tapes from the six-year saga.
- News and analysis of the Murdaugh family murders of Paul and Maggie and the 2023 trial of Alex Murdaugh.
- When a young woman goes missing, police are led to a local man's barn full of horrors;
- Sue Klebold, the mother of Columbine gunman Dylan Klebold, discusses her relationship with her son, what happened inside her home leading up to the tragedy, and the victims of the April 20, 1999, massacre. In addition, Diane Sawyer examines teenage mental health, warning signs of a child in crisis, and what can be done to prevent the next school shooting.
- The ex-wife of Justin Ross Harris -- who is currently serving a life sentence for leaving their son in a hot car, resulting in the child's death -- talks about the incident.
- 1978– Unrated7.8 (15)TV EpisodeFormer first lady Michelle Obama talks about her new memoir, "Becoming";
- The legacy of former President George H.W. Bush;
- An interview with actor Robert Blake, 14 years after he was acquitted of murdering his wife, a case that remains unsolved;
- A look into the past of Cary Stayner, who terrorized Yosemite National Park in 1999, murdering four women; interviews with former FBI agents Jeff Rinek and John Boles; an interview with one of Stayner's original intended victims;
- The case of Jason Dalton, a former Uber driver, who terrorized the city of Kalamazoo, Michigan, for eight hours on Feb. 20, 2016, killing six people and seriously injuring two others;
- When a 19-year-old woman's car is found on a New Jersey bridge, a classmate comes forward with information that helps authorities discover what happened;
- Interviews with Erin de Roche and Kati Reynolds, the daughters of Karl Karlsen, who nearly got away with murdering his wife Christina Karlsen and son Levi Karlsen, who died in a house fire;
- Melanie McGuire, a New Jersey woman who was sentenced to life in prison, in 2007, for the murder of her husband Bill McGuire, discusses the case and maintains her innocence;
- A look into the events leading up to the deadly shooting on the set of "Rust" and the pending investigations into what when wrong;
- An interview with the mother behind a sinister plot to poison her husband and children;
- 1978– 2hUnrated7.7 (16)TV EpisodeDiane Sawyer decodes the mysteries behind the Heaven's Gate cult, including an exclusive interview with Rita D'Angelo, a member who left the group;
- 1998 Arlington, VA: James Christopher Johnson finds his fiancee Andrea Cincotta dead. Police force a confession from him after 28 hours of interrogation. 20 years later, he is indicted and found innocent. Bobby Joe Leonard pleads guilty.
- The investigation of the Gilgo Beach murders, featuring interviews with family members of the victims and key players in the case, including Suffolk County Police Commissioner Rodney Harrison and Suffolk County Defense Attorney Ray Tierney;
- When a pro athlete is murdered, police embark on an international chase for the killer;
- Actress Leah Remini talks about her experience with and ultimate break from the Church of Scientology, which she chronicles in her memoir, titled "Troublemaker: Surviving Hollywood and Scientology". During the interview, she discusses Tom Cruise.
- Christopher Waide is convicted of the 2014 murder of 19-year-old Lea Porter.
- After running out of gas while driving alone in the desert, a young woman survives five days with limited food and water, before being found by a rescue team.
- Victims, eyewitnesses and first responders share their accounts of what happened during the mass shooting at the Route 91 Harvest festival.
- Thirteen siblings are found captive inside a California home; what life was like inside; details on the alleged abuse.
- Children rapidly develop devastating psychiatric and neurological problems, following strep throat;
- A high school cheerleader is shot by an ex-boyfriend, who claims it was an accident, during an attempt to get her back;
- A series of rapes in Northern California. The rapist moves down the coast, his crimes escalating to murder.
- In 1989, five teenagers are convicted of attacking a jogger in New York's Central Park; 13 years later, the young men's convictions are overturned; interviews with the woman who was attacked and with police involved in the case;
- Payton Leutner speaks out for the first time, after her two friends stabbed her 19 times and left her for dead in the woods of Waukesha, Wis. to prove themselves to a fictitious character known as "Slender Man";
- When a woman secretly records her husband's affair, she snaps and kills his girlfriend and former boss and then herself;
- Edward Shin kills his business partner Christopher Smith, then he hatches a tall tale to cover his tracks.
- On the anniversary of Anna Nicole Smith's death, her daughter visits the most influential places in her mother's life;
- A courageous mother, whose daughter mysteriously went missing, finds justice with the help of another mom she never met;
- High school principal Joe Bryan spends more than 30 years behind bars for his teacher wife Mickey Blue Bryan's murder, which many believe that he didn't commit;
- A serial killer targets women he knows; firsthand insight from a criminal profiler;
- Florida 1990: Marlene Warren was shot and killed by Sheila Keen Warren who was dressed as a clown to deliver balloons and flowers. Marlene's son witnessed the shooting. The case went cold for decades until it was solved by DNA in 2017.
- When 12-year-old Polly Klaas is snatched from her bedroom, the kidnapping shakes a small town.
- When four young women go missing, police hunt for a serial killer roaming the interstate; John Quinones explores the families' quest for answers;
- 20/20 updates the story of Ethan Couch a teenage drunk driver who killed four pedestrians, but later was sentenced to probation due to his "affluenza." Last month Ethan and his mother skipped to Mexico after video surfaced of Ethan violating his probation. They were arrested in Puerto Vallarta and Ethan sits in a Mexican jail fighting deportation.
- The murder of a 12-year-old child in October 2011 is investigated, after the man accused of strangling the boy to death, was acquitted of the crime.
- Computer programmer and businessman John McAfee discusses being named a person of interest in the murder of his neighbor and the resulting tumult. He also discusses what his life is like today.
- Exclusive interviews, photos and footage related to the Nixon Watergate scandal.
- A woman is convicted of murdering her own mother; she speaks out from prison; interviews with an ex-boyfriend and others close to the case.
- A woman's kidnapping is initially dismissed as a hoax by authorities; she recounts details of the kidnapping and the anguish it caused;
- After being found naked, beaten, and unconscious by a utility worker, a 21-year-old woman who had been staying in a nearby Miami airport hotel finds she has no memory of her attack and rape;
- In 1989, 18-year-old Amanda "Mandy" Slavik disappeared while jogging in her rural Washington hometown, and later, police discovered her body in a nearby river; news of her rape and murder shook her tight-knit community, but with no leads and police unable to find a DNA match to her killer, the case went cold for decades; thirty years later, a jury found a former neighbor of Mandy's, Timothy Bass, guilty, finally bringing an end to the case;
- The case of Dallas housewife Darlie Routier; after claiming to survive the brutal stabbing that left her two sons dead, she urged the police to find the alleged intruder; in a shocking twist, she became the No. 1 suspect and was sentenced to death;
- 1978– 2hUnrated7.5 (24)TV EpisodeThe story of Dorothy Stratten (1960-1980), the 1980 Playboy "Playmate of the Year", who was murdered by her estranged husband, just as her entertainment career was taking off;
- Drug Enforcement Administration (DEA) agents Eric Triana and James Mannick and NYPD detective Danny Politowski help carry out a sting operation, where women secretly drug and rob wealthy men; interviews with Jennifer Lopez and Cardi B (Hustlers (2019));
- The strange Dalia Dippolito case is featured, revealing what happens when reality-TV and hidden cameras converge with a real-life murder-for-hire plot; Dalia Dippolito, currently in prison for solicitation of murder, became the buzz of southern Florida after authorities secretly filmed the situation;
- Fort Hood soldier Vanessa Guillen, brutally murdered in April, captured international attention and sparked a #MeToo movement in the military. Cameras profile Vanessa's family as they tirelessly advocate for justice. Along the way, Vanessa's parents, Rogelio and Gloria Guillen, and sisters, Mayra and Lupe Guillen, share emotional memories of Vanessa.
- A killer terrorizes idyllic California neighborhoods in the 1970s and 1980s, evading authorities as he lives among his victims, for over four decades;
- A family discusses their seemingly perfect husband and father's deadly secret;
- 1978– Unrated7.5 (12)TV EpisodeA 6-year-old boy begins living as a girl during kindergarten; a 10-year-old, born a boy, lives as a girl; a transgendered 16-year-old takes testosterone injections.
- This installment details the true-crime story of Nicole "Nikki" Addimando's shooting and killing of her domestic partner, Christopher "Chris" Grover on September 28, 2017 in Poughkeepsie, New York.
- After a teen vanishes, the family searches for answers, but police see a suspect closer to home;
- An illicit love triangle, a wife with a double life, and one big lie leads to murder. This installment follows married couple Jaime Faith and Jennifer Faith, and Jennifer's former high school flame, Darrin Lopez.
- More than a decade after a teenage girl vanishes from a popular tourist destination, her killer is brought to justice; interviews with the FBI team who broke the case wide open and identified her killer;
- When a 16-year-old girl disappears, police have a surveillance video showing her getting into an unknown vehicle shortly after midnight; when the truth of her disappearance finally comes to light, the community is shocked by who is behind the plot;
- 20/20 goes to, Lansing, Michigan to investigate the scandal surrounding Conservative Tea Party Representatives Todd Courser and Cindy Gamrat who were caught having an affair. Courser attempts to bury the scandal by encouraging an aid to publicly email a false set of lurid allegations against him. The aid refuses to assist in the cover-up and, after being dismissed by Courser, goes public revealing the attempted cover-up and the affair. Courser and Gamrat are forced to resign.
- Playboy model and reality TV star Anna Nicole Smith is remembered, 10 years after her sudden death; new information about her glamorous and mysterious life is revealed through conversations with Larry Birkhead and others who were close to her.
- How terrorist organizations target young Americans online and what makes them vulnerable; the efforts of technology companies to counter terrorist propaganda.
- North Korean leader Kim Jong-un and his fractured family's 70-year dynastic rule; interviews with those who knew Kim Jong-un and his assassinated half-brother, Kim Jong-nam.
- The sexual abuse scandal surrounding Larry Nassar, former doctor for the USA gymnastics team; harrowing stories of abuse spanning over two decades; details on how the abuse went unaddressed for so long.
- Actress Rebecca Schaeffer is shot point blank at the door of her Los Angeles home by her longtime stalker;
- Ted Bundy's longtime girlfriend, Liz Kendall, and her daughter, Molly, open up about their lives with the serial killer; Ted Bundy: Falling for a Killer (2020) producer/director Trish Wood;
- Celebrating the life, legacy, and storied career of the actor, as well as the cultural imprint he made both on and off screen, along with tributes from celebrities around the globe and information on the medical condition he fought in private;
- A world-renowned surgeon is caught in a web of lies and deceit by his fiancee;
- A twisted love triangle, involving a married couple and a young bar hostess, results in her disappearance;
- A woman frames her boyfriend for murder and implicates herself, but the real culprit is a serial killer;
- A step inside the new "West Side Story", from director Steven Spielberg, featuring interviews with the cast and crew, and discussions with Puerto Ricans on the role this story has had on their lives.
- Lubbock, Texas: Investigating the July 2012 "love triangle" murder-for-hire death of pathologist Joseph Sonnier by killers David Neal Shepard and Thomas Michael Dixon.
- Former Iron River Police Chief Laura Frizzo ran a tiny police force of only four officers in a tight-knit community in the Upper Peninsula of Michigan. She shares the story of the investigation of the 2014 death of Christopher Regan.
- When an inmate and a corrections officer vanish, authorities question whether it's a kidnapping or a forbidden romance;
- When a boy is kidnapped while riding a bike, parents, police, and a blogger work to bring him home;
- A beloved professor is murdered; inside the trial;
- When a beloved mother is killed, police uncover clues in the accused killer's diary;
- When a college student vanishes from a mall parking lot, police hunt for her killer;
- A mom's mysterious death leads authorities to investigate a connection to a missing engagement ring;
- Amanda Berry and Gina DeJesus on their abduction by Ariel Castro and their plans for the future.
- The story of a baby boy stolen in 1964 from a hospital on the day after his birth in Chicago. Without anything more than their reckoning, the FBI believed it found the child in 1965 and returned the boy to the parents, Fifty years later, questions and a DNA test showed that Paul Joseph Fronczak was not their biological offspring .
- 20/20 updates the the case of Brian Carrick who disappeared from his Johnsburg, Illinois, stock boy job in December 2002. Originally, co-worker Mario Casciaro was arrested and convicted of murder despite the lack of a body. Recently, developments in the case, however, have overturned his conviction and have led to his release from prison.
- 20/20 looks at the May 2010 murders of Army veteran Sam Herr and his friend Julie Kibuishi. They were killed by former community theater actor Daniel Wozniak who killed Herr to steal $60,000 and, then, murdered Julie Kibuishi in order to throw the police off his trail.
- Information leads to the dismissal of charges against a man convicted of the murder of Chandra Levy.
- A Canadian woman, who served time for cat-fishing professional basketball player Chris Anderson and a 17-year-old girl who had a social media presence, discusses the reasons behind her scheme.
- A jury convicts a former FBI agent and his daughter of second-degree murder in the death of the daughter's husband; pretrial interviews with the defendants, crime-scene evidence and audio documentation of marital trouble.
- Footage of U.S. border officers accused of encouraging a 16-year-old to drink a dangerous liquid to prove he's not a smuggler; cases of border agents and officers being accused of abusing those crossing the border.
- Authorities use DNA to find Joseph DeAngelo, the suspected Golden State Killer; interviews with attack survivors and others close to the case;
- A mid-flight explosion, on a Southwest Airlines flight from New York to Dallas, forces pilot Tammie Jo Shults to make an emergency landing in Philadelphia; interviews with passengers on the flight and those who knew the heroic pilot;
- A look at the two most important women in Prince Harry's life: his mother, Princess Diana, and his soon-to-be bride, Meghan Markle;
- An 11-year-old boy, convicted of first-degree murder, gets his conviction overturned, after seven years in juvenile detention;
- Televangelists Jim and Tammy Faye Bakker's religious empire and the sex and financial fraud scandals that engulfed it;
- A man convicted of murder has his conviction overturned by an appellate court and waits to see if a higher court agrees it should be overturned;
- The case of Martin MacNeill, whose wife Michelle MacNeill was found unresponsive in her bathtub by her 6-year-old child; it took authorities five years to charge MacNeill, a wealthy doctor and father of eight, with murder;
- Pamela Smart, who was sentenced to life in prison, without parole, for her involvement in the 1990 murder of her husband, talks about the case and the possibility for a new chance of freedom;
- Rodney Reed attempts to clear his name and overturn his conviction for the 1996 murder he maintains he did not commit; interviews with the victim's mother and sisters;
- A group of 20-year-olds, whose mothers were pregnant with them when their fathers were killed in the 9/11 attacks, and their families talk about their lives;
- In this special edition of 20/20, Erin Brockovich returns to Hinkley, California after 10 years. Also featuring "Rebel" TV series creator and executive producer, Krista Vernoff.
- A man whose double life led to murder; first interview with his ex-wife;
- The murder of Lyntell Washington, a Baton Rouge, Louisiana educator who was voted Teacher of the Year, is investigated; when authorities found the pregnant woman shot in the head, they were left with a cryptic clue from her 3-year-old daughter, who was found wandering nearby;
- Three women -- one missing, one murdered, one kidnapped -- and the clues leading to a killer;
- Elizabeth Vargas is interviewed by Diane Sawyer, in the Season 40 premiere, about her secret struggle with alcohol and anxiety, as revealed in her memoir, "Between Breaths".
- A conservation with Keith Papini, husband of Sherri, the California mom who disappeared on Nov. 2, 2016, and was later found bound and injured 150 miles from her home.
- Todays theme is the Truth and Lies: The Family Manson.
- A Tennessee high school teacher, accused of kidnapping his 15-year-old student, causes a 38-day manhunt that ends with the two being found in northern California; interviews with people close to the case.
- Authorities set up an elaborate sting operation to catch a Houston couple, who were allegedly attempting to hire a hit-man to kill their exes.
- Interviews with women who have come out with sexual harassment accusations against Harvey Weinstein.
- Interviews with key people connected to the 2014 case, in which two 12-year-olds stabbed their friend 19 times and left her for dead, in an effort to appease the mysterious fictional character known as Slender Man.
- A son orchestrates a murder-for-hire plot that injures him and kills family members; the son is convicted of first-degree murder and sentenced to death; the son's father pleas for the death sentence to be commuted to life in prison.
- Authorities maintain that a woman committed suicide, even though her family believes she was killed by her deputy sheriff boyfriend;
- Investigation of murders committed by criminals ordered to wear ankle-bracelet monitoring devices and the failure to stop the crimes.
- DNA detective CeCe Moore helps two people, who were abandoned by their mothers after birth, locate their biological families;
- An in-depth look at the legendary public, professional and personal life of Sen. John McCain (R-Ariz.);
- In September 2015, Kelley Clayton is brutally murdered in her upstate New York home, in what turned out to be a murder-for-hire plot orchestrated by her husband Thomas, who was well-known in the community as a former minor league hockey star;
- Today is the question: Can Words Kill?
- Insight into serial killer Ted Bundy's vicious past and crimes, featuring new interviews with key players, including surviving victims and those who were instrumental in helping place him behind bars;
- Police apprehend a man in Texas, robbing two banks with his son and daughter, after he uses manipulative tactics to rope them into participating in the crimes;
- John Lennon's close friends and colleagues provide insight into his life and lasting legacy; radio reporters talk about the last interview John Lennon did with them, the day that he died;
- In the 1970's, a notorious serial killer makes a winning appearance, as a contestant on a popular dating show, in the midst of his killing spree;
- New details in the case of a missing mom, who secretly ran an expensive escort business;
- The latest details on the Murdaugh family murders and the alleged financial crimes of Alex Murdaugh;
- Norfolk, Virginia: This installment outlines David Wayne Hoshaw Jr.'s 2007 double-murder of a mother, Vonda Goyena, age 74, and her daughter, Angelique Goyena, age 35. Three years after the murders, David Hoshaw pleaded guilty.
- Multiple women are murdered, during a Texas police hunt for a serial killer;
- When a young mother goes missing, police question a pastor, the ex-husband, and even a local ventriloquist; but authorities are left wondering: who would want to harm Tricia Todd?
- Vivian Shillander left the cult, Children of God, with but one of her five children. Her husband, Richard Shillander supported by the cult, did not let the other four children leave with her. Vivian, aware of the reputation of the cult that encourages adult sex with minor children, and other abuses, got a court order awarding her custody of the children, hired two private investigators, and flew to Bangkok, Thailand, where her husband and children were located and set up a sting operation to bring the children back home to America with their Mother.
- When a 16-year-old girl accuses a classmate of raping her at a party, the investigation divides the small Alabama town.
- Investigation into the questions that still remain surrounding the 1997 murder of designer Gianni Versace.
- Investigation into the 2002 murder of Christa Worthington and whether the man, who was convicted, actually committed the crime.
- The 2011 disappearance of a 20-year-old Tennessee woman and the ensuing investigation; interviews with the victim's family members and others connected to the case.
- A mother opens up about her fight to prove her son's innocence of murdering a 19-year-old college student.
- An interview with Elizabeth Thomas, who was taken at age 15 across country by her Tennessee high school teacher in 2017; the incident led to a 38-day nationwide manhunt;
- The case of Felix Vail, accused of murdering his wife in 1962.
- A behind-the-scenes look at Mary Poppins Returns (2018), as the iconic character returns to the big screen. Included: interviews with the cast and crew;
- A couple, their son, and their housekeeper are murdered in their DC mansion and the mansion is set on fire;
- A woman, convicted of killing her husband, claims she was blacked out during the murder, that she says occurred during a home invasion;
- The rise of Silicon Valley star Elizabeth Holmes and her technology company, Theranos, and their fall amid accusations of massive fraud;
- A woman, who believed she was conceived by an anonymous sperm donor, discovers her biological father is actually her mother's former fertility doctor;
- The latest news and developments about COVID-19, people affected by the virus, and widespread changes sweeping the nation;
- Marni Yang, a single mother of three who is serving a double life sentence in the murder of football player Shaun Gayle's pregnant girlfriend, talks about the case and her petition for a new trial;
- A man, who claims to have killed his wife while sleepwalking, opens up about the incident, his children, and his life in prison;
- A deep dive into the evidence in the Breonna Taylor case, from 9-1-1 calls and interrogation tapes to jail house calls, surveillance photos and hundreds of pages of police records;
- First Lady Jacqueline Kennedy's never-before-heard conversations are revealed.
- The 1998 death of Julie Jensen of Pleasant Prairie, Wisconsin, is investigated; the case included a letter, written by Jensen, that said suspicion should fall on her husband Mark, if anything happened to her;
- St, Paul, Minnesota, April 25, 2010: This installment details the murder of Heidi Firkus by her husband Nicholas "Nick" Firkus.
- When a woman is killed in a small Texas town, a secret diary reveals the killer's motive;
- A Florida university campus is on edge, when a student disappears;
- A look at the life of Elliot Rodger, the perpetrator of a killing spree in Isla Vista, California on May 23, 2014.
- A physician's wife dies in the bathtub after a facelift. The husband and his mistress attend the funeral of his late wife. Accident or murder?
- 20/20 recalls the O.J. Simpson case and the controversial trial where he was acquitted of the murders of Nicole Brown Simpson and Ron Goldman. It then examines the wrongful death civil trail brought against Simpson and looks at a video tape of the deposition he was force to make for the trial.
- Detectives suspect that the 2014 murder of a Florida State University criminal law professor may be the result of a family feud.