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- A teenage diabetic fails to keep an appointment, and Mac regrets coming to the assistance of an old colleague who's due in court for negligence. Anoushka is worried about a bruise on a patient's shoulder.
- Heston is called to see a pregnant woman whose husband has returned after 2 years missing and finds her living with his brother. Al and Niamh's pub quiz date goes awry when Oliver turns up. Kevin meets sexy Poppy at a new club.
- Niamh breaks up with both Oliver and Al. A smitten Kevin goes to see Poppy, still pretending that he's a top music promoter. Mandy sees a very agitated man who's acting strangely with his daughter. Heston has another session with Oliver.
- In a continuation of the very first episode, a couple face up to the harsh realities of living with Alzheimer's. Mac gets involved when Derek turns up at the surgery. Jo is upset with Ross.
- Helen gets approached by a young girl, concerned about her mum. Ruth sees a troublesome kid with asthma and a bump on his head. Joanna arrives at work in a fancy new hat.
- Heston and Howard interview for a permanent doctor, disagreeing over terminology, with Heston overruling Howard to choose no-nonsense Al Haskey. Chris feels used when Croatian student Edin requests a particular host family - and it turns out he has a crush on the daughter. Rob and Lynn prepare to reel in Andrei but Karen is beginning to wonder if they are having an affair.
- Daniel helps an old gambling buddy who finds himself homeless and beaten up, only finds over £180,000 of cash strapped to his waist. Kevin has a shock when Poppy turns up at the Campus surgery. Al tells Niamh how he feels.
- Walter turns up at the Campus surgery to see Dr Carmichael. He won't see anyone else so waits all morning, much to Mrs Tembe's annoyance. Mandy goes to comfort a sleepless Catriona. Kevin tells a pushy Poppy that it's all over.
- Daniel attends the funeral of Elvis - the Karaoke King of Letherbridge. Howard gets a shock when Heston sleepwalks into his bed. It's Poppy's 16th birthday and she's determined to carry on her relationship with Kevin.
- Rob's investigation into the beating of a policewoman at at masked Eco demo gets more complicated than he imagined. Ayesha has run ins with Mrs Tembe and Zara. Poppy's mother discovers who Kevin really is.
- Jimmi gets the go ahead to forge links with a local bereavement service, though the boss there has other ideas. Kevin goes to a girls school to teach sex-ed, though is spotted by Poppy. Mandy is worried about Catriona.
- Heston, Kevin and Al all have the perfect evening planned. Kevin has Poppy over; Al have Niamh over for a meal, and Heston invites a reluctant Jimmi and Mandy around to listen to opera.
- After walking out of her piano audition with her dad, Rachel faints. She's taken to see Zara who discovers she's given birth, but where's the baby? Howard confronts Heston about his night time activities.
- Zara is determined to get to the bottom of Kevin's argument with Poppy's mother, especially when they both turn up at the Mill to see him. Al deals with a new student who's been scammed over his accommodation.
- Cherry has a shock when she wakes up, tries to be all cuddly with Scott, only to find him dead. She calls the police, but is really upset. Pulled crying from the body, she is arrested, interrogated, and locked up. She cries a lot. Karen tries to help. So does Jimmi.
- Charlie and his girlfriend break up. Although upset, he is soon having sex with her hot, ex model mother. Catriona wants some anti depressants though Mandy wants to talk. Kevin and Poppy bump into them in the Icon Bar.
- Daniel sees a man who's had a heart procedure and is pushing himself too much at work. Catriona sees DC Mitchum, who doesn't take her complaint too seriously. Poppy's mother finds out she's seeing an older man, so takes her to the doctors.
- Jimmi's patients boyfriend is an angry ex-con who doesn't believe she's gone to the doctors, and Jimmi gets involved in the violence. Daniel has to put his Botox clinic presentation to Julia and Lily. Cherry thinks she's pushing too hard with Scott, and he's acting strange.
- After nightmares about a dead Scott, and waking up in a police cell, Cherry's day goes from bad to worse. It seems Scott had been dealing heroin. Simon helps a musically gifted boy who is being bullied in school. Zara acts all happy, and is secretly kissing Jack.
- An investigation at work is troubling Rob, and it seems to involve Cherry's fiancé Scott. Two old neighbors are at war in their gardens, and Daniel gets involved.
- Cherry goes to Scott's funeral, though he keeps phoning her, and turning up wanting to chat! Or is it all in her mind?
- Cherry surprises Scott when she moves in at 8am, not pm. Michelle deals with a traveling student and her runaway parents.
- Cherry deals with an old romantic and a love triangle. Both she and Heston have big decisions to make.
- Daniel seeks the help of an ex con. Christine is rude to Ruth, and then dumps a big shock on Heston.
- It's Sarah's birthday, and she and the girls drag a downbeat Helen out for a wild girl's night out. Helen gets really drunk, starts a fight, and gets arrested. Jack proposes to her.
- Daniel has a not-so-good revelation about Scott, and just after Scott and Cherry have slept together! Lily deals with a troubled, truant of a teenager. Heston and Lily try to come to terms with Christine's request.
- Luke is struggling to find a sitter for his daughter while he has an interview for a job. Michelle tries to help, but is shocked by Luke's desperate behavior. Simon and Will have the perfect date. However, is Will too good to be true?
- Daniel suggests to Julia that they start a botox clinic, so they go to check one out. Simon has to deal with a young boy, who while recovering from glandular fever takes a fancy to the 'Manny' of the house. Heston spends some time with Steven. Scott asks Cherry to move in with him.
- A newborn baby puts a strain on two of Julia's friends. Ruth meets Scott, and Cherry spends the evening with him and Simon. Heston has a heart to heart with Lily, and tells her that Jerry is Steven's father, and his ex-wife is dying.
- Lily gets annoyed when Heston tells him about Steven coming to stay with them when his ex wife dies. A wheelchair bound old lady crime fighter gives Rob a big tip-off. Simon and Michelle tell Cherry that they think Scott is not all he seems.
- Daniel helps a vicar who finds his year old son with tears of blood. His wife thinks it's a holy sign.
- Helen says "yes" to Jack's marriage proposal.
- In a special episode, which the cast filmed themselves in their own homes, the Mill staff deal with the first few weeks of lock-down.
- Rob gets called to a house, only to confront a disturbed teenager brandishing a bottle. Cherry has a date with Scott, so tries to learn up about wine. He takes her to the cemetery though. Lily and Heston try to deal with the fact that he has a son.
- Timid, bookish Amy risks everything to gain membership into her brash twin sister Cookie's gang. Is there a darker motive behind her reckless quest for approval?
- Lily deals with a flu bound teenager, whom she wants to take it easy due to his chemotherapy. But it's his birthday. Michelle disobeys Daniel when she tries to go out in heels. Simon and Cherry end up at a gay club, where Cherry meets a hot bloke!
- Lily is surprised when she discovers a stalker on campus. Ruth starts her assertiveness course, unfortunately accompanied by Heston who discovers he has a lot to learn. Daniel tests out a new cologne much to Zara and Simon's amusement.
- Billy's recently discovered long-lost brother moves in, with terrible consequences. Heston organizes a French theme day at work. Cherry and her new man go out on a date. Heston has a shock when a woman from his past turns up.
- Al and Rob hit the streets looking for evidence, while Daniel and Zara receive a rude awakening. Bear tries to help a patient who thinks she's being stalked by Joe Pasquale.
- Steve returns to work following the death of his wife and has a bit of a rough day.
- Dr Rawlings suspects a wife of committing a mercy killing.
- Al goes to Hardernwick for a night of beer only his Reverend friend doesn't turn up. Alone, he discovers the place to be haunted, especially when he finds a whistle at the local church, blows into it, and summons something evil.
- How does Helen choose between a patient's life and their beliefs, when they need a blood transfusion? Mac has lunch with sexy drugs rep and old friend Lyn Baker. Caroline turns up for work with a hangover.
- It is the day of Caroline's mum's wedding and most of the Riverside staff attend. Steve has something on his mind after an unexpected visitor. Faith finally deals with her tormentors.
- 'Mac' decides to sack Jo. She leaves the health center in tears. Caroline has sex with her mother's fiancée.
- Family loyalties are put to the test when Helen's sister turns up. Rana sees a patient with an inflamed gland. Nurse Ruth deals with the curious case of Mr Hyde.
- A couple face a dilemma over their unborn baby. A hot young patient develops a crush on Dr. Rawlings
- Alzheimer's destroys a loving couple's life.
- An overanxious mother is proved right. Steve comes into work, trying to recover and grieve after the death of his wife. Rana's gone walkabout. A mother comes in complaining that her boy stinks.
- The surgery staff have to deal with an unexpected delivery. Mac visits an elderly man with a terrible smoking problem, and a serious mugging. Rana sees a patient who's carrying a roast turkey. Anoushka continues to tease Steve.
- Ben tends to a model who is forced to reevaluate her life when a skin condition threatens her career. Helen worries that Mac is avoiding visiting Kate and baby Kieran in the hospital. Jude deals with a stubborn man from her past who won't leave her alone. Mac finally visits Kate and baby Kieran, but he's drunk. After finishing work for the day, Ben stumbles upon a house fire and rushes in to pull people out.
- On a busy day at the surgery Dr. Brendan McGuire deals with a stubborn woman with a black eye, Dr. Steve Rawlings is faced with a girl who refuses to talk, and Dr. Caroline Powers goes on some frustrating house calls.
- Caroline suspects she isn't hearing the whole story from a 16 year old who claims she's been raped. Ruth gives holiday jabs to a reluctant woman who's about to get married. She's also got some massive rashes.
- A doppelganger of Simon is wandering around Letherbridge, pretending to be Simon. Cherry meets Scott's dodgy business colleagues. Julia has it in for Zara, but all Zara wants in some testosterone. She then breaks down on Ruth.
- Dr Helen puts on a skirt and unbuttons her top to charm film bloke Dominic into providing her with evidence on tape which she hopes will exonerate Dr Marc.
- Helen declares that she is not in love with Mark, so he leaves with Robert, very upset. Helen cries. Ronnie returns from Australia declaring that his marriage to George is over.
- A desperate Susie Lucas kills herself in prison.
- Helen considers a change of image - something sophisticated. Mac has a game of golf with a patient who gets ill only on Thursdays. Ruth visits an OAP with a troublesome neighbour. Chris wants to show Helen his hob.
- A woman is forced by her boyfriend to see a doctor, but are his concerns genuine?
- Caroline gets quizzed about the death of an elderly patient's husband. Rana creates friction by taking one of Helen's patients.
- Mac makes a promise when a family wants to put an elderly relative in a home. She's Helen's patient, and Helen and Mac have a professional disagreement about his decision.
- George has a nasty shock when neither Faith nor Helen can hear her baby's heartbeat.
- Jo plans a special Christmas with her nan, Rana receives puzzling laboratory results and Jessie tries to enlist Mac's help in a business affair.
- Mac and Kate slip off for a secret bit of passion - it's time. Steve discovers why a student won't leave the digs she's sharing with her boyfriend.
- A PC sees Steve as she wants to try a young girl mugger for murder. Rana sees a married man with an SDI. On house calls, Caroline sees a man with a germ obsession, and makes a shocking discovery.
- A pregnant mother presents Rana with a dilemma when she pleads to be induced so that her cancer-stricken husband can see his child before he dies.
- Faith is first to bed handsome new Dr Marc.
- Caroline grows concerned over her future in the practice, and Mac sees a private patient with a dickey heart whose decision to use the NHS provokes arguments from all sides. Helen sees an elderly patient who's refusing a hip operation.
- A ditsy, but sexy, new receptionist, Sarah Finch, starts at the Best Practice. She impresses Dr. Eliot though by helping to fix his car.
- The staff at Riverside struggle to cope without Mac's help as Kate lies in hospital in a critical condition following her fall. A teenage boy struggles with the embarrassment of seeing Dr Jude Carlyle after a problem with a testicle.
- George tells Ronnie she is going back to work and that he can stay at home to look after Bracken. Mac flags down Al Burgess, a farmer on his way to a very important business meeting, to help rescue an unconscious hill walker.
- A patient of Helen's has to choose between her own sight or the life of her baby. Steve helps out with a patient's 5-a-side league. Caroline and Steve get angry over a new partnership promise, and Caroline sees a woman with big breasts.
- Mac returns from Canada to find chaos and death at Riverside following the siege. Faith mourns the death of Jerry.
- The pressure builds on Mac, as he faces up to the first day of the murder trial, and Caroline gets bogged down with her own problems at the surgery.
- Rana finds himself at the heart of the storm when Caroline confronts creepy Eddie over his wish to give their marriage another chance, revealing secrets from her past in a tense day.
- It's time for Dr Marc's trial.
- Katrina and Faith make an effort to impress new Riverside medic Dr. Marc Eliot, but he's too preoccupied with helping a patient to notice.
- Various people hook up at Mac's engagement party
- Rana says no to Caroline; Leigh says yes to Steve; Helen moves back in with Phil and the kids.
- The parents of an unborn child who may have Down's Syndrome, struggle to come to terms with the situation. Mac and Kate argue over Mac going to his daughter's graduation on Kate's birthday. Steve and Jo battle it out to see who's fittest.
- The verdict comes in on Mac & it's not guilty.
- Helen's patient, an eighteen year old swimmer, wants a double mastectomy due to her having the breast cancer gene. A happy patient of Steve's gives him a sure thing on the horses.
- Ben ends up in hospital on life support, following the fire.
- A man refuses to tell his wife he has testicular cancer
- Rana and Caroline attend a holistic medicine fair where Caroline is picked up. Compromise is called for when a father's medical beliefs are challenged.
- Steve sees a woman who's been diagnosed with Huntingtons, a hereditary disease, but has it been passed down to her daughter? An emotional Caroline turns to Rana for support at lunch, but then necks a few vodkas.
- Jimmi discovers that Amanda has been lying to him about having cancer, and Helen is shocked when Marc's fiancée turns up.
- The doctors move into the all new Mill Health Center, and start getting it ready for business.
- Helen tries to get to the bottom of a young child's hyperactivity, and help her desperate mum. Mac is thrust into the middle of a factory strike, and Jo tries to chat up the local IT guy.
- Chloe's date around Ben's apartment got off to a bad start when she accidentally set fire to it. The box of fireworks under the table didn't help things. Ben got trapped under lots of rubble, Chloe tore her fishnets.
- Mac treats a man who has lost his job and is accused of being a drunk, and Steve tries his hand at a spot of DIY that needs to come up to scratch.
- Twin brothers take their gambling addiction too far. Anoushka sees a sick friend who's ill with cancer. Kate sets up a hidden camera to try and find out where the biscuits are going.
- A woman that's been diagnosed with Chronic Myeloid Leukaemia has to choose between a bone-marrow transplant or chemotherapy. Also she is giving her autistic seven year old son drugs off the internet which she informs Dr Rawlings aren't helping the boy. Rana's nephew turns up for a day's work experience.
- Mac gets attacked by a junkie while on a house call at a dodgy flat. Jo gets worried about a hot date.
- 'Mac' calls an urgent meeting among the Doctors to discuss Jo's stealing, drug addiction, her attempted suicide and her assisting Jesse to kill herself. Caroline snogs her mother's fiancée.
- Kate has unsettling news for Mac, and Steve wonders about Anoushka's true feelings as he helps a boy with an eating disorder.
- The behaviour of a policeman attacked during a robbery gives the doctors cause for concern
- When a couple expecting quads are given a difficult choice by Brendan, the incident makes Kate realise that her own biological clock is ticking.
- Follows up episode 101's storyline of Sally and Dale Witchell. Steve helps patient Sally Witchell who has gone into early labour. Caroline confides in Rana.
- A couple seek marriage counselling, and Helen sees the counsellor, who's feeling a bit nauseous. Jo and Anoushka come to the aid of an alcoholic.
- Helen returns from a forbidden liaison with Chris to discover her son has been rushed to hospital, and Max faces a grilling in the witness box.
- Steve has a hangover after a night drinking with his brother Chris. Rana has difficulty persuading parents to let their asthmatic son take life-saving medication. Chris makes an excuse to see Helen at the surgery and has a good old flirt.