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- A rough-and-tumble trucker and his side kick face off with an ancient sorcerer in a supernatural battle beneath Chinatown.
- A mild-mannered guy, who is married to a monstrous woman, meets the woman of his dreams, and schemes to find a way to be with her.
- The world is shocked by the appearance of three talking chimpanzees, who arrived mysteriously in a U.S. spacecraft. They become the toast of society, but one man believes them to be a threat to the human race.
- A teenage genius deals with the usual problems of growing up, on top of being a licensed physician in a difficult residency program.
- The lives and trials of the staff of a major hospital in Chicago.
- Film version of Jacqueline Susann's best-selling novel chronicling the rise and fall of three young women in show business.
- Dr. Shutt may have brain damage after his aneurysm, so a new neurosurgeon, Dr. Lisa Catera, is brought into the hospital. Dr. Austin gets trapped on an elevator with a sexy electrician.
- Watters causes permanent damage when he participates in a charity boxing match. Diane intervenes when Billy wants to amputate a patient's leg. Dr. Grad suggests sewing maggots into the leg. Aaron and Camille make their divorce final.
- A potentially brain-dead donor comes into the ER. With doctors from all over Chicago waiting, the body is first declared brain-dead, then after a re-examination they find he's only in a coma. The doctors bicker over what to do.
- Catera tries to get a terminally ill patient into a cancer test study. One of Shutt's patients confesses to murder. Cronk struggles with the decision to put his seriously ill dog to sleep.
- Nyland treats an amnesiac who wanders away and is mistaken by Phillip for an old medical student. Aaron operates on a death row inmate who begs Aaron to kill him on the table, dying before the state has a chance to execute him. McNeil suspects an old girlfriend of abusing her mother.
- Aaron and Samara vacation in LA, where Aaron learns a valuable lesson about savoring life. Keith clashes with Dennis when a wealthy woman tries to improve urban life by paying for the sterilization of drug addicts. Billy endures a visit from his flighty mother. Phillip tries to produce an audio tape on surgery.
- Shutt has difficulty coping with a patient's death; Kronk is tempted by the advances of his daughter's baby sitter.
- Dr. Shutt counsels the family of a teenage suicide. McNeil and Hancock try to determine whether a young patient is the victim of parental abuse. Wilkes refuses to treat his absentee father after he's admitted to the hospital. Phillip, stinging from repeated rejections from his son, urges father and son to reconcile.
- A multiple birth has Chicago Hope hopping. Bobby and Diane help a very unusual patient. Aaron's dog needs therapy.
- Austin has to give a physical exam to a former astronaut scheduled to fly the space shuttle. An old friend of McNeil's arrives at Hope dying of pancreatic cancer. Shutt treats a young rabbinical student who attempted suicide.
- Dr. Hancock gets caught up in a political movement after accusing a white police officer of shooting a homeless African-American; Dr. Austin learns to fly a plane.
- Phillip travels to Wyoming to recruit Jack McNeil, an orthopedic surgeon. McNeil refuses, for reasons unknown. McNeil is haunted from memories of the Oklahoma City bombing. New Trauma chief Keith Wilkes is in hot water after he removes narcotics from a patient's intestine and flushes them. Grad returns from Africa and is offered a general practitioner position. Dr. Austin cares for her dying father. Ron Silver continues to appear.
- McNeil performs a hand transplant; Austin becomes a crewmember on the space shuttle; Watters' ailing childhood friend asks him to donate a kidney.
- Jack and Jeremy help a teenage girl who was born a boy. Gina and Francesca treat an elderly woman suffering from Alzheimer's.
- Aaron announces he's leaving Chicago Hope for a teaching position at Harvard. Shortly thereafter he begins to suffer from a brain aneurysm. The aneurysm sends him into a trance state where he hallucinates several strange fantastical experiences, including Chicago Hope doctors in song and dance sketches and Jeffrey Geiger's advice on life.
- Phillip searches for answers after his son is shot in the head and dies. Jack continues his pursuit of Lisa. Sara Wilmette meets a young cancer patient.
- Phillip reconnects with an old flame when her son is hospitalized. Jack decides to pursue a relationship with Lisa, dumping Karen Wilder. Grad is busy with a patient who insists she's pregnant despite evidence to the contrary.
- A 'girls only' weekend getaway at McNeil's cabin goes horribly wrong for Kate, Lisa and Diane, when Grad is assaulted by a native backwoodsman. The three doctors deal with the attack differently. Austin, still affected by an attack in her college days, responds with anger. Lisa remains cool and rational while Diane is paralyzed with fear.
- Nyland and Hancock deliver a Christmas present to Ricky Jackson for Kronk. Gunfire erupts while they're in the apartment, forcing the doctors to stay until the gunfire abates. While there, Nyland does his best to save a man impaled on a pipe, while Dennis braves bullets to bring in medical assistance. Diane worries that she might have contracted HIV from Bam-Bam, a laboratory animal. Camille is brought in after suffering a seizure while dancing. Billy treats a high-school baseball phenom with possible colon cancer.
- A steroid using wrestler with a knee injury learns she may have cancer. Aaron and Gina come up with a plan to use hypothermia on a young girl to better her chances of surviving brain surgery. Keith's son Ray asks his dad for help with a sick tarantula.
- Watters is reunited with his Vietnam C.O. when the colonel is admitted suffering from rheumatoid arthritis. Phillip is baffled by the colonel's refusal to accept treatment. Kate has her hands full when Sara is traumatized by the accidental death of a Little League teammate. Wilkes and Nyland have a role reversal, with Danny staying calm and serene and Wilkes acting the hothead, over Ricky Jackson's use of ER supplies.
- Jeffrey Geiger returns having bought controlling interest in the hospital and he fires Austin, Kronk, Yeats, Catera, and Hancock. They decide to pursue their options. Aaron consults with the new pediatric surgeon, Gina Simon about a new born baby. And a young surgeon who was hired by Austin before her dismissal arrives and Geiger puts her to work.
- Laurie has a big surprise for Jeffrey. An inner-city doctor suspects his teenage patient may have breast cancer.
- A 12-year-old girl arrives for surgery to correct a severely cleft palate and suffers serious complications from another birth defect. A young nurse interferes in Dr. Shutt's care for the comatose Dr. Antonovich.
- Diane, several weeks overdue, finally goes into labor. Wilkes tries to keep an abusive man away from his family by admitting him for back pain and doping him up. Jack and Lisa take a ballroom dance class.
- An old friend of Jack's shows up in the ER with a minor gunshot wound and a major heart defect. The conjoined twins return to the hospital and when Jeremy discovers one of them has developed pancreatic cancer, she tries to convince them to have separation surgery.
- Dr. Wilkes takes flak from Dennis for not giving back to his community. Billy has a tough decision to make when a childhood friend show up at his apartment in the early morning hours with a bullet in him. Diane believes Billy's friend may have been involved in a savage beating.
- Kronk and his dog move into Nyland's posh apartment after Billy's place burns down. Yvette White initially agrees to donate her late son's organs to others, but withdraws her consent when she discovers his heart will go to a Nazi-in-training. Birch finally gets up the nerve to invite Diane to lunch.
- 1994–20001hTV-148.1 (39)TV EpisodeAfter suffering a medical emergency, Hugh experiences care at Chicago Hope firsthand. A woman who went into a coma giving birth reawakens after 15 years and is reunited with her husband and daughter. A man is being denied coverage for life saving heart surgery by his HMO who consider the procedure to be experimental.
- Dr. Sutton is shocked when his three ex-wives arrive at the same time, two of him tell him they're lovers, the other is admitted to the ER. Austin pursues the chief of surgery office with zeal. Hancock's sister comes in after being beaten by her husband. Danny Nyland hits on the fiancée of a wealthy patient.
- Dr. Simon performs brain surgery on a friend suffering from Parkinson's and then has to deal with the man's mother when things go wrong. Dr. Geiger deals with a doctor who is doing research into human cloning and with an elderly patient who is ready to die.
- The hospital's administrator dies while "with" Angela. Phillip is made acting administrator. Geiger tries to give a patient, who is waiting for a heart transplant, some more time by giving him the heart of a baboon. Thurmond upon learning that Nyland refuses to treat a woman with AIDS, considers firing him, unless Nyland can convince him not to. Thurmond also decides to use Geiger's baboon to treat the woman with AIDS by transplanting it's bone marrow to her.
- The doctors race to save a boy who was submerged in icy waters for over three hours. An AIDS patient fights for his life and Dr. Infante has a startling request for Dr. Geiger.
- A new mother is shocked when she gives birth to white and black babies; Dr. Austin makes a rude remark and is threatened with a lawsuit.
- Laurie invites Jeffrey, Aaron, and Camille to her wedding, which needs to be held soon due to the minister's impending transfer out of the asylum. Dr. Sutton operates on a fetus. Birch and Watters testify at a hearing on medicare, but are surprised when they're ambushed by a politically minded senator. Camille displays signs of depression.
- A troubled Dr. Geiger seeks a blessing from his institutionalized ex-wife so he can continue his relationship with Dr. Infante. A dying AIDS patient hopes Hancock can arrange a surgical procedure that would allow him to see one more sunrise.
- Dr. Geiger performs a risky heart operation on an overweight mob killer who's a key witness for the FBI. Two weary residents plot a practical joke to get even with the dour Dr. Geiger. The budding relationship between Dr. Shutt and Dr. Antonovich takes an unexpected turn.
- A father must choose which of his two dying children will get his liver donation. Dr. Rose Weber suffers a seizure at work. Aaron and Gina deal with their budding relationship.
- A teenage boxer whom Dr. Watters helped train suffers a seizure. Birch lends support to a pregnant girl. Dr. Shutt is audited by the IRS and gets an unpleasant surprise.
- Phillip and Aaron present their plan to buy Chicago Hope to the staff, where it's met with resounding complaints. Aaron tries to define his relationship with Maricela. The ER treats a patient with numerous psychosomatic ailments. Kronk gets in trouble when he performs a lung reduction operation, a procedure vetoed by the patient's HMO. Billy visits the patient's HMO representative, the 'freaky' Jonathan Saunders, to straighten things out.
- An explosion sends a dry cleaner to the ER. Dr. Kadalski is pressured to change his unorthodox methods when he treats a man who compulsively pulls out his hair. A fearful Birch lets off steam at Jeffrey as baby Alicia's condition worsens.
- Dr. Wilkes faces certain fears when his son shoots a friend while playing with his father's handgun; one of Dr. Shutt's patients is attracted to him.
- Watters' old romantic rival checks into the hospital in need of a heart transplant. When a heart finally arrives, Austin performs the transplant against her will, believing that the wealthy patient bribed the donor family. Aaron and McNeil work together to help a man with a rare disease that is causing his muscles to contract. Wilkes is affected when a gang member violently shoots up the ER. Billy officially asks Diane to marry him. It's mentioned that Nyland is gone, it doesn't say how or why.
- A woman refuses treatment because of religious beliefs; Dr. Hanlon fights to provide free treatment; multiple piercings cause a young man's staph infection and heart problems; the hospital's Web site stirs angst among the staff members.