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- The kids build a float and only have a night to drive the float to the parade. The float breaks down in a bad neighbourhood. Can the kids recover?
- A suicidally despondent trumpet player finds himself in a bizarre world where he seems to be invisible to everyone, except for one helpful other musician.
- Dr. Andy Campbell joins the Rittenhouse Women's Health Center as Lu's new partner; on Andy's unofficial first day, she clashes with Lu over a woman who had an illegal kidney transplant and a patient of Lu's who refuses to get her young son vaccinated.
- Kiki Yeung as the comedic characters from her award winning one woman show "Second Chances For Grace" interviews guests from comedians, film directors, actors, producers, artists to stay at home moms and social media influencers.
- Lu, Peter, and Lana host a dance-a-thon and a free mammogram clinic for Breast Cancer Awareness weekend; Lu tries to intervene to help a patient keep her breast and her job after her mammogram reveals a lump; Dana gets some unexpected results of her breast cancer clinical trial and learns that her mother has breast cancer.
- Amy has to decide whether or not a 9-year-old boy who is the product of his mother's brutal rape should be placed in the custody of his paternal grandmother; Maxine encourages a young artist to channel his anger more positively and meets Ignacio's ex-wife and kids; Kyle has a hard time being supportive of Heather's pregnancy.
- Jo meets the Bailey family. Police officer Bill and schoolteacher Stacie are having a hard time with their 2 kids: 6-year-old Jadyn and 2-year-old Billy. Jadyn acts disrespectful to her parents and prefers to sleep in the hallway or her parents' bedroom instead of her own bed while Billy throws temper tantrums and still sits in a high chair. Can Jo help this family?
- A filmmaker locks himself in his house to face up to his loneliness and the ghosts of three couples, the protagonists of three of the films he made over 31 years, from the fall of the Berlin Wall until today. An essay on loneliness, absence, unease and the weight of social circumstances on individuals. A film about Havana, as lived and filmed under a blazing sun.
- Nick's former geometry teacher Mr. Farb is hired to teach at Gerald R. Ford High School. Meanwhile, Sophia convinces Marco to build a birdhouse for Yaroker's class, but Tasha believes that girls are just as capable at carpentry as boys are.
- Lu discovers that two teenage girls have been poisoned by a girl at their high school they have bullied; a patient of Andy asks her to endorse her new heart-health diet book only to end up in the emergency room suffering from a heart attack.
- Lu treats a female acquaintance of Marc's who is discovered to be pregnant and claims that Marc is the father; Andy becomes a health food advocate at Lizzie's school; Kayla asks Peter to pose as her fiance when her ex-boyfriend comes to town.
- Jo visits the Bullard family in Colorado. Jenn and Bryce are busy with their plumbing business along with raising their two kids: 6-year-old Brycie and 2-year-old Rylan. Brycie back-talks his parents while Rylan refuses to go to bed at night, keeping Jenn up all night. Jenn and Bryce have different views on raising their kids. Can Jo help these parents get on the same page and get control of their household?
- Jo visits the Burnett family. Working stay-at-home dad Michael is juggling his work and his two sets of twin children: 3-year-old Joseph & John, and 16-month-old Molly & Michael. Schoolteacher Joanne comes home to a brood of toddlers who demand her attention and does chores which Michael calls "women's work." Can Jo help this family?
- Nadine Jordan, the accused killer of Torres and McNamara has been convicted of their murders and sentenced to life in prison which upsets Moreno. The District Attorney prosecuting a radical terrorist discovers that his daughter is kidnapped and held for ransom until the terrorist is released.
- Jo visits the Christiansen family. Colleen and Chris are struggling with their two boys: 7-year-old Corey and 3-year-old Chase. The boys disrespect their parents by talking back, kicking, pinching, and biting them. Even though Chase is 3 years old, he still drinks from a baby bottle. Chris and Colleen are at odds with disciplining the boys and the whole family tends to yell a lot. Can Jo help this family?
- Jo returns to the UK to help the Collins family who are having trouble with their 4 kids: 10-year-old Ben, 9-year-old Lauren, 6-year-old Joshua, and 4-year-old Joseph. Mother Karen is a stay-at-home mom while dad Jason manages at a bakery. Ben and Joseph are physically aggressive and destructive: swearing, spitting, and tearing up the house. Can Jo help this family?
- When Lu's mentor misdiagnoses a patient, Lu contemplates whether or not to tell her that she needs to retire; Andy treats a couple's two young daughters who are diagnosed with a rare genetic disorder; Andy's daughter, Jesse faces bullying over her back brace.
- Lu treats a young orphaned boy with attention deficit disorder and discovers that his foster guardian has been using the Ritalin that she prescribed to him; Dana helps the wife of a high-powered real estate developer who has been abusing her.
- After Frank Duskey is hospitalized after fighting with Todd in the previous episode, Todd can't help but second guess himself. Meanwhile, Brett and Colleen go over the books and realize there is no way that they can keep the team alive unless they make some cuts.
- After a councilwoman comes to the clinic to see Dana a few gang members are upset when they are unable to get insurance and the councilwoman refuses to listen. Seconds later, an unknown gunman begins shooting at the clinic which accidentally injures the councilwoman; Peter treats a woman who was traumatized during the shooting and learns that she grew up in Cambodia during the war, but soon discovers the real source of her pain.
- After Dr. Emerson asks Nick to teach a seminar on human sexuality, Nick faces trouble when Tasha's parents think that he told their daughter it's okay to have sex with her boyfriend; meanwhile, Marco defends Miles from a bully, but later when Miles purposely seeks out another confrontation with the bully, Marco refuses to help Miles out, teaching him not to take advantage of a favor.
- Dana is shocked when Dr. Jackson's wife, Susan comes into the ER with bruises which at first she thinks that Robert gave them to her, but Susan is later diagnosed with multiple sclerosis; Lu deals with Marc's mugging at school and a group of drug-addicted prostitutes who want their tubes tied for money.
- Andy cares for a princess from a foreign country whose family wants her to have surgery to fix her deformity so she can be ready for an arranged marriage and is approached by a woman who wants to regain her virginity before she gets married; Lu helps out a woman with Alzheimer's cope with her tragic past.
- Brent feels like his life is falling apart after Colleen turns on him after she decides he seduced her to get his job back, Michelle announces that she's going to school in England and he is facing extradition charges in the United States. Meanwhile, Duff makes a deal with the government to save the Steelheads.
- When a family-values orange juice dealer is interested in having one of the Steelheads as a spokesperson, things get complicated when it's discovered that the player chosen is cheating on his wife; Renata has an unpleasant encounter with a potential investor for the team.
- Brothers Jackson and Grady Rhames look for options to help save their independent hip-hop record label, Sweetback Entertainment; when they try to steal their rival label's hottest rapper, the label sends a gang of thugs to assault the chief counsel for Sweetback; meanwhile, their younger sister Jade goes out with rapper VersIs.
- Former Steelheads goalie Al Tremblay becomes the team's new head coach; Simpson is given divorce papers; Michelle finds herself caught in the middle between her father and husband; Duff risks his personal fortune for one last chance at the cup.
- A group of renegade surfers challenges the male-dominated professional surfing world for the shared goal of equality and change.
- The unit goes after the leader of a criminal empire who is extorting money from several businesses in Manhattan. The case gets personal for Barker when he is reunited with an old girlfriend. Meanwhile, JC and Nina try to find where their relationship is at after sleeping together.
- When Marco is too upset about the end of his relationship to complete a poetry assignment, Nick tells him about his own failed relationship in order to relate to Marco better, but things go wrong when he unwittingly asks Marco's former girlfriend out on a date.
- Brett uses his connections to lift the suspension of hockey goon Frank Dusky so he and Todd can fight on the ice, but during the game, things go terribly wrong; the issues between Mark and his wife Rayanne get worse after Rayanne's father dies and Mark chooses to play hockey instead of being with his family.
- A psychopath second grader starts knocking off his schoolmates one by one in order to maintain control of the lunchline. Cafeteria hysteria!
- The staff at Rittenhouse Hospital fear for their jobs when Octavian Systems takes charge of the hospital; Lu clashes with Ben when she learns the hospital plans on cutting screening test for newborn babies; Andy suspects a patient of hers is on the FBI's Most Wanted list.
- Two days before her wedding, Amy has to precede over a felony murder case involving a 14-year-old boy who is charged in the shooting death of the son of a police officer; on her big day, she starts to have second thoughts about getting married.
- Jo visits the Larmer family. Ed and Judy are having trouble with their 4 children: 4-year-old John, 2-year-old twins Jessica & Justin, and 11-month-old Joey. The kids are destructive, breaking practically everything in their house. Their grandma doesn't want the kids in their house because she fears they'll break something. Jo discovers that the main problem with the family is the parents' bickering and fighting. Can Jo help the parents solve their differences and help control their out-of-control kids?
- Jackson attempts to chase Lady Bryce's man away because their relationship is distracting her from recording her new album, but his plan ends up backfiring; Jade develops a friendship with Nick; Monica wants to be more involved in the family business after learning about the label's financial issues.
- Jackson has trouble with one of his artists, A Diva when her antics start to threaten her future with the label; Monica thinks about joining Sweetback while Olivia sees her husband's true loyalty to the label; meanwhile, Jade spends the night with Nick.
- Jo meets the McMillion family. With dad Jonathan in Afghanistan, mom Cheryl is left alone to raise her three sons: 9-year-old Ryan, 7-year-old Hunter, and 3-year-old Garrett who are constantly fighting and yelling. Cheryl is at her wit's end and begs for Supernanny's help. Can Jo help this family?
- After Dana treats a commercial pilot who has a degenerative brain disease, she is conflicted about whether or not she should break doctor-patient privilege to prevent her from flying another plane; Lu discovers that a couple's daughter has a genetic disorder called Tay-Sachs, but both parents are Catholic.
- Lu and Dana clash over the case of a woman with AIDS and how she chooses to treat her child; after Dana treats the woman who has taken her HIV-positive son off of his medication because it makes him very ill, she reports Lu to the Chief of Staff; Lu reveals that she told his mother it was okay to take him off his medication, but Dr. Jackson requires that he goes back on his medicine. Dana receives a visit from a talk-show host who wants to do a story on artificial insemination; Peter makes a house call that doesn't go as well as expected.
- Amy hears the case of a boy who runs away from home hoping to join the circus as a gymnast; Maxine discovers that a foster girl lied about being sexually assaulted by a homeless man so she wouldn't get in trouble; Lauren's boyfriend, Victor winds up in the hospital after getting hit by a car.
- When Nick makes excuses about his students' mischievous behavior, Mezz warns him that they won't respect him as a teacher since they view him as a friend. Nick finds out that what Mezz said is true after discovering Sophia at a nightclub and makes her leave, so the students get their revenge on Nick by misbehaving during Dr. Emerson's evaluation of him.
- When Jordan starts arriving to school late fails to do his homework, ignores his friends and drinks alcohol at school Nick discovers that the reason for Jordan's behavior is because his parents are divorcing. Meanwhile, Dr. Emerson announces a carnival at school in order to help with the school's budget crisis.
- Jo visits the Orm Family. Tammy and Shawn are having a hard time controlling their three rambuncious sons: 8-year-old Chandler, 6-year-old Caden, and 3-year-old Declan. Chandler cops a major attitude with his parents. Caden beats up on his little brother and refuses to eat meals. Declan is learning bad behavior from his big brothers and also sneaks out of the house to wander all over the neighborhood by himself. Tammy is soft on the boys when it comes to discipline while Shawn is more tough. Can Supernanny help this family?
- Baby sends a henchman to take out Max after he learns that Max told the parole board he's still dangerous; Devon takes drastic measures against Jackson which leaves the future of Sweetback Entertainment uncertain; Grady realizes he's in love with Karl; Jade breaks up with Nick and goes back to Versls.
- After a female basketball player collapses on the court, Lu discovers that she is taking steroids and wonders if the whole basketball team is also taking them as well; Dana is surprised when an unconscious woman shows up in the ER with her name and phone number in her pocket, but she's never met her before.
- In order to keep her South Philadelphia women's free health clinic open, Dr. Luisa "Lu" Delgado turns to Rittenhouse Hospital for financial help. But, however it is discovered that Dr. Dana Stowe blames Lu for ruining her breast cancer study. The Chief of Staff, Dr. Bob Jackson tells Dana to take a tour of the clinic to see if Rittenhouse should help fund it; meanwhile, Dana has to tell one of her patients that her sister might be at risk for ovarian cancer in which her ovaries would need to be removed.
- As Lu and Ben's relationship begins to develop, his ex-wife comes back into the picture in search of a job and faces a health scare; new resident Kayla Thornton begins working at Rittenhouse; Jesse's friend ends up in the ER after overdosing on cough syrup in order to get high.
- After a videotape reveals one of Sweetback's artists committing a sex crime, Jackson and his crew are at odds about whether or not they should turn it over to the authorities; Jade considers Nick's invitation to go to London with him; Grady reveals to Versls that he slept with his wife.
- Dana and Lu find it hard to work together. Dana has to tell a surrogate couple that their child will be born with potentially severe (they could be mild effects) mental birth defects which makes them question whether or not they can raise a special needs child; Lu investigates a clinic that supposedly gave a woman a hysterectomy due to bleeding fibroids, but it turns out that they never gave her one at all.