- After refusing to marry her adopted brother, a half Native-American Mexican woman flees to marry a Native man.
- Ramona refuses to marry her step/adopted brother, Felipe. She runs away and is found by an American Indian that she falls in love with and marries. She has a son with her Indian husband but the husband and child both die. Ramona goes crazy with grief and runs into the wilderness. Felipe finds her, saving her life and bringing her back to health, and the two reconcile.
- In early California, Señora Morena (Vera Lewis) runs a large sheep ranch. Her son and heir Felipe (Roland Drew) has fallen in love with her adopted daughter Ramona (Dolores Del Rio), though she loves him only as a brother. It is sheep-shearing time, and the Temecula Indian Alessandro (Warner Baxter) arrives with his band to take on the task. Alessandro and Ramona fall in love, but Señora Morena tells Ramona that she can't allow her to marry below her station. She also lets Ramona know that her mother had been an Indian, which convinces Ramona that there is no barrier to her marriage to Alessandro, and they elope into the mountains. Several years later Alessandro and Ramona have a child and a house near an Indian village. The child becomes ill, and dies after the white doctor refuses to treat Indians. Then a group of "marauders" (white Californians) attacks the Indian village, massacring the inhabitants, burning the houses, and stealing the livestock. Ramona and Alessandro escape to the mountains, but Alessandro is accused of stealing a horse and killed. Ramona goes mad and flees blindly through the woods. Felipe finds her, suffering from memory loss. Her memory is returned when she hears the guitar music of her youth, and she and Felipe reconcile.
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