Mr. Drysdale follows the Clampetts and Miss Jane to Hooterville where they are spending Christmas. He takes Ellie's bear Fairchild with him and gets himself thrown in jail in a little town. Sam Drucker shows up to help.
Mr. Drysdale is sick and Dr. Granny springs into action with a chimp as a nurse. But Ellie's bear Fairchild has taken a liking to granny's "flu" remedy. During this, Mrs. Drysdale tries to impress society matron Mrs. Van Ransohoff.
Jethro's new plan is to become a big-time talent agent, and his first action is hiring beautiful Babs and Bunny. Cousin Roy, told he has musical gifts, arrives but Jethro refuses to accept him as a client which upsets the other Clampetts.
Jethro agrees to take on cousin Roy as a client but then he changes everything that made the banjo player likeable. Granny, Jed, and Ellie are dismayed but a hit record happens in spite of Jethro.
Jethro is evicted because his 50-cent allowance won't cover the rent. The other Clampetts take over the space: Granny will cut hair or pull teeth, Jed will sharpen tools and whittle things, and Elly is the pretty receptionist.
With the Clampetts established "in business" in Jethro's vacated office space, a building inspector visits to find out about their business operations on the 5th floor.
Granny provides Homer Cratchit with a baldness cure which makes the other employees curious about what's going on on the 5th floor. One secretary sets her sights on marrying Jed.
Jethro meets Mrs. Drysdale's guru and decides he wants to be one also. Granny thinks it's all nonsense but when she tries to put a stop to it the followers find her common sense inspiring and make her the head guru.
The Drysdales now jog, so the banker can get the account of Jason Detweiler, head of a running club. The Clampetts don't understand the concept, leading to misunderstandings, then Elly and Jethro become enthusiastic.
Famous singer Pat Boone is in the neighborhood and smells Granny's cooking. He wanders into their backyard and the Clampetts befriend him, thinking he's a hill country man down on his luck.
Granny is worried that Elly May is an old maid at 20 while Jed is concerned about Jethro joining college protesters. They both miss the hills, so they decide to head back to the Ozarks, which upsets Mr. Drysdale.
After settling in at Silver Dollar City Jed, Granny, and Ellie greet old friends. Granny meets up with her old rival Elverna Bradshaw and restarts her feud. Jethro continues his college protests back in California.
Miss Jane lends a hand in Granny's race to get Elly May married-off before Elverna Bradshaw's daughter, and finds an unwed winner wandering in the woods.
The family begins to make plans for Elly May's upcoming wedding to Matthew, but Mr. Drysdale finds himself preoccupied during the entire matter by the prospects that the wedding will lead him to lose his biggest account.
After Elly's wedding plans fall through because Matthew is unavailable, the Clampetts leave Silver Dollar City. They head to New York City where they encounter their old "friend", conman Shifty Shafer, who sells them Central Park.
Honest John continues to show the Clampetts around New York trying to "sell" them as many landmarks as possible. The police have given him a twenty four hour notice while Miss Jane and Mr. Drysdale try to get there to stop the con job.
The Clampetts settle on their new property of Central Park and Jed starts building a log cabin. Granny looks for possums but meets muggers instead giving them a lesson in manners. Mr. Drysdale pleads with them to return to California.
The Clampetts return to their mansion and Mr. Drysdale claims the veterinarian Dr. Graham is perfect for Elly. But Granny, after breaking her glasses, mistakes a seal for the veterinarian, leading to a series of misunderstandings.
Shorty Kellems comes to Beverly Hills for a visit. Mr. Drysdale misunderstands a conversation and mistakenly believes Shorty is wealthier than Jed, and begins to indulge him in every way possible to win his account.
Jethro is leading a wild life with Shorty. Granny is determined to get Shorty to return to the hills. Meanwhile, Mr. Drysdale would like Shorty to invest his money with the bank... enlisting the secretarial pool to persuade him!
Mrs. Drysdale's favorite nephew, Lance "Jetstream" Bradford, who after ten years is still a 2nd Lieutenant in the Air Force, comes for a visit. Milburn reluctantly gives him a job.