In the first half of the film, after an interesting opening lettering simulating comic books, a beautiful cinematography and a cunning edition (often with dark humor) depict a wide range of sexual depravation situations (sometimes combined with mysoginy, violence, and work harassment). Those bizarre cases are interwined with a debate between psychiatrists, in a noir footage, about the possible causal connection between those dire social events and the usage of illegal drugs. One of those experts is José Mojica Marins, the director himself, who is also known as his character Coffin Joe, then merging reality, the story of the present movie and also his previous films (besides a horror comic book character who also appears in a newsstand). It is mentioned that another scentist, Sérgio, made experiments with LSD with four patients to investigate that issue. Then, Coffin Joe appears in a TV show being interviewed by intelectuals about his role as filmmaker in Brazilian cinema, being judged as in a court. After that, the movie continues showing Sérgio's experiment to find out if there is a relation between LSD and perversion. After going with the four patients to watch Coffin Joe's films in a theater, he shows them images of that character and uses syringes to inject the solution on them. That last quarter of the film is partially coloured, what does not happen in rhe whole rest of the film. Situations even worse and weirder than in the beginning of the film take place inside their thoughts and minds. In those scenes, Coffin Joe shows his sadism and mysoginy, and have magic powers that did not appear in his three first movies portraying the character. The four human guinea pigs have macabre hallucinations, and the young woman suffers lots of violence, just like undistinguishable unknown people who are present in that hellish nightmare. Off course the whole film is an excuse to exploitation, and there is very little story between the weird real or oneiric situations. However, José Mojica Marins does try innovative cinema aestethics throughout the film. In the end, researcher Sérgio explains his experience (no spoilers here), when they are also shown in the mentioned TV show. Coffin Joe has the elements to keep making his films.