Peter O'Toole was originally cast as Toby Dammit. After he pulled out, Federico Fellini contacted a London casting agency and asked them to send the most decadent actors they had to Rome to see him. They sent Terence Stamp and James Fox, and Fellini chose Stamp.
While filming the "Metzengerstein" segment with his sister Jane Fonda and brother-in-law Roger Vadim in Roscoff, Brittany, Peter Fonda would spend up to 4 hours a day working on the script that would become Easy Rider (1969). Terry Southern, who had worked on Barbarella (1968) with Vadim, visited the set and would help Fonda with his script, getting a co-writer credit on "Easy Rider" in the process.
In Federico Fellini's segment, Terence Stamp plays an actor arriving in Rome to do a film, and as they leave the airport to go into the city he suddenly sits up and asks where his Ferrari is; he was promised a Ferrari. This is a humorous reference to a behind the scenes situation on the film The Witches (1967) from the year before, when Clint Eastwood was enticed to play a small role in exchange for a Ferrari.
Its release in Great Britain was long-delayed until early 1973, when it had only a handful of showings. under the title "Tales Of Mystery". As of 2019, it has never yet been shown on British television and has a DVD/Blu-Ray release in Britain under its American title "Spirits Of The Dead".