A man falsely convicted of killing his wife takes Mark hostage in order to prove his innocence. (A train transporting prisoners derails, sending him to the hospital--partly inspired by The Fugitive (1993).)
While Norman tries to strong-arm Mark and Jessie into attending a fund raiser, Steve deals with his new girlfriend, who just might be responsible for a series of cop killings.
Jesse encounters a man in the parking garage who's in cardiac arrest. After he runs off for help, he returns to find a different man, and no one will believe Jesse's story. Meanwhile, Norman has to work with an attractive donor.
Community General is at odds as money-minded Marsha McArthur threatens to cut costs by cutting short the careers of older MD's, starting with Dr. Sloane. When she ends up dead, Dr. Sloane is the prime suspect.
A string of murders occurs with the same killer signature. One of the victims supposedly called Mark, but it is after she was known to be dead. The case becomes personal when the killer starts calling Mark.
Mark gets involved in the string of murders when the killer starts calling Mark. It gets more personal when the killer attacks Amanda. She manages to escape. Mark and Steve get closer to finding the killer.
A surgeon kills a man on the operating table for insurance money. Foul play is expected as the identity of the man becomes questionable. Mark reluctantly helps Steve with the investigation since the surgeon is a good friend of his.
Sloan helps a lawyer probe a drive-by shooting at a high school which left a popular teacher dead. But her stubborn insistence that a Korean teen is responsible makes finding the real killer a challenge.