A magician is out for revenge on three people in Metropolis, including Clark. He uses voodoo to strike Clark with his greatest fear, long suppressed. Meanwhile, Lois' mother takes over plans for the wedding.
It's up to Jimmy Olsen to decrypt the information on a laptop taken from corrupt NIA head Trevanian. But suave spy Jack Olsen, Jimmy's long-absent dad, is assigned by Trevanian to get the information back - and he has a license to kill.
Lois is abducted to an alternate universe where she is dead, Perry is running for Mayor against Tempus, and Clark isn't Superman. She and H. G. Wells must find a way home and convince Clark to accept his destiny before Tempus kills Perry.
As the stress of their approaching wedding becomes too much, Lois and Clark turn to investigating a bizarre story about frog-eating clones, unaware that one of them has replaced the President of the United States.
Lois has been captured by Lex Luthor and replaced by a clone. While Clark gradually comes to the discovery that the woman he married is an impostor, it becomes a race to track down the real Lois before she is killed by her clone.
Lois's clone offers to help Clark in exchange for her freedom. Lois, who still thinks she's Wanda Detroit, starts falling in love with Lex Luthor, who works to convince her to kill Superman and change into a new body.
Clark entrusts the amnesiac Lois to a respected clinic - where one of her doctors brainwashes her to become an assassin, and her other doctor abuses his position in an effort to win Lois's love for himself.
With Lois now believing herself to be in love with Dr. Maxwell Deter, Clark's attempts to tell her the truth get help from an unexpected source: Bad Brain Johnson's brother Herkimer, whose latest invention makes people prone to suggestion.
Lois and Clark go to Lois's high school reunion. There, she learns that her friends' spouses have disappeared. She decides to investigate this when something starts happening to Clark. He is beginning to shrink in size.
While discussing buying a house with Lois, Superman is put through brutal tests to his strength, ingenuity, and morals by the mysterious Zara and Ching.
After being approved in Zara and Ching's tests, Superman learns that they want him to leave the Earth (and Lois) forever and go back with them to rule New Krypton, or the planet will be ruled by the evil Lord Nor.
Clark takes up the throne of New Krypton, but secretly backs out of consummating his marriage to Zara and plans to return to Earth. However, Lord Nor also takes a liking to Earth, and moves to colonize it.
Lord Nor brings Superman to trial for his plans to usurp Nor and leave the Kryptonian throne with no heir. Meanwhile, Lois learns that the kryptonite held at S.T.A.R. Labs has been stolen.
H.G. Wells warns Lois and Clark that they must go back in time to break a curse put on their past lives; otherwise, Lois will die of a terminal disease after they consummate their marriage.
Embittered scientist Vida Dodson creates a machine that drains youth, leaving Jimmy and several others old men in a matter of days. Lois is distracted from the case when she learns that Superman's powers grant him extreme longevity.
Clark and Lois have a lot in common with their new neighbors, until they find out Bob is an assassin whose next target is an eccentric recluse Lois plans to interview.
A real estate agent's plan to frighten people into selling their homes spirals out of control when he accidentally summons the spirit of a murdered housewife.
Lois' promotion causes problems in her marriage to Clark. They have their first major fight after she kills one of his stories, preventing him from uncovering a plot. Two delinquent brothers try to destroy Superman.