- Senator Kelly's proposal of a Mutant Registration Act echoes the efforts of U.S. Congress' efforts to ban Communism in the United States. Kelly brandishes a list of known mutants, and exclaims "We must know who these mutants are and what they can do!", a paraphrase of Senator Joseph McCarthy, who claimed to have a list of known American Communists working in the government.
- Kelly further questions whether mutants should be allowed to teach children in school, which mirrors the Section 28 issue (the banning of homosexual teachers in United Kingdom schools, against which Sir Ian McKellen protested).
- A deleted scene has Storm teaching a historical lesson about how Emperor Constantine's decree in 312 A.D. ended the persecution of Christians in the Roman Empire, and eventually led to Christians becoming the majority, which foreshadows Magneto's plot to force world leaders to accept mutant-kind by mutating them.
- Magneto talks about the Act having mutants "in chains, with a number burned into their foreheads." The situation he describes, is similar to what happened to Jews and other nonconformists in Nazi Germany (which Magneto experiences in the first scenes).
- Magneto's last lines contain the phrase "By any means necessary." This phrase was coined by civil rights revolutionary Malcolm X. The relationship between Magneto and Professor X has been compared, respectively, to that of Malcolm X and Dr. Martin Luther King, Jr., both of whom held differing philosophical views.
The majority of the cast do not match the nationalities of their characters: Hugh Jackman/Wolverine (Australian/Canadian), Famke Janssen/Jean Grey (Dutch/American), Halle Berry/Storm (American/Kenyan), Sir Patrick Stewart/Professor X (English/American), Sir Ian McKellen/Magneto (English/German-Jewish), Anna Paquin/Rogue (Canadian-Kiwi/American), Shawn Ashmore/Iceman (Canadian/American), and Rebecca Romijn-Stamos/Mystique (American/unknown).