Courteney Cox remarked about her relationship with then husband David Arquette in relation to the Scream franchise "I was just flirting with David on the first one, I was sleeping with him in the second, and we shared a trailer in the third."
David Arquette and Courteney Cox met on the set of Scream (1996), dated while shooting Scream 2 (1997), and married a month before principal photography of this movie began. They cut short their honeymoon in order to film it. Cox added "Arquette" to her name, as seen in the credits.
Throughout the film, Sidney (Neve Campbell) can be seen wearing the Greek letters around her neck that were given to her by her boyfriend Derek (Jerry O'Connell) in Scream 2 (1997), shortly before he was killed.
(At around sixteen minutes) The green outfit worn by Parker Posey while on-set is the same one worn by Courteney Cox in Scream (1996). All sets for "Stab 3" were replicas of the originals, since the sets were destroyed after Scream (1996) wrapped.
Patrick Dempsey was hired the day before shooting began. He had one night to learn three big dialogue-heavy scenes.
Jason Mewes, Kevin Smith: (At around nineteen minutes) Jay and Silent Bob, the popular drug dealer characters from Clerks (1994) and other movies, appear as tourists visiting Sunrise Studios who spot Gale Weathers (Courteney Cox) and mistake her for Connie Chung.