The series was originally scheduled to have 52 episodes, but due to having lower ratings than its predecessor Galaxy Express 999 (1978), the series was completed with only 42 episodes.
Yukino Yayoi is seen to have a tiger-striped cat in the series. This cat is a trademark of creator Leiji Matsumoto, and is affectionately known as "Leiji," after his creator.
In creating the "Queen Millennia" manga, Leiji Matsumoto was inspired by the Japanese folktale "Taketori Monogotari," or "The Tale of the Bamboo-Cutter": a princess from a magical kingdom in the moon is adopted by a bamboo-cutter and lives amongst humans for a time. Another title for this series is "Shin Taketori Monogatari," or "The New Tale of the Bamboo-Cutter."
In the series, Hajime attempts to reach a compromise between the peoples of LaMetal and Earth, and at the end he tries to help people escape from La-Metal by using a helicopter. However, in 1000nen Jo'ou (1982) he is a student of Yayoi and flies an A6M Zero fighter plane into battle with LaMetal's troops. Another difference is in the "Queen Millennia" manga, where he receives a cybernetic implant which increases his intelligence and enables him to fly space ships.
While Professor Amamori begins to lose his hair due to the shock of his monumental discovery in the "Queen Millennia" manga and Queen Millennia (1981), in the series he keeps all his hair.