Lawrence Talbot, aka the Wolf Man, first appeared in The Wolf Man (1941), played by Lon Chaney Jr. The same-named neighbor of Dave Seville and the Chipmunks bears no resemblance to Chaney's likeness.
Brittany wears a different outfit in this movie. Instead having a pink shirt, skirt and yellow scarf from Alvin & the Chipmunks (1983) and The Chipmunk Adventure (1987), she wears a blue or violet shirt and a pink skirt.
Neither Alvin, Simon, or Theodore had colored eyes in the previous film Alvin and the Chipmunks Meet Frankenstein (1999).
Maurice LaMarche (Lawrence Talbot) and Rob Paulsen (Mr. Rochelle) previously worked together as the voices of Pinky and the Brain in the Warnerverse.