By holding B when you select Shade Man's level (provided you haven't already beaten him), a different piece of music will play. The music is from another Capcom series, Ghosts And Goblins.
Contrary to popular belief, NOT the first Mega Man game to let you collect currency to trade for items at a shop. The Game Boy Mega Man IV introduced this function. This is, however, the first game on a CONSOLE to have this feature.
The game is a sequel to Mega Man VI, not Mega Man X2 like so many gaming magazines falsely stated.
First appearance of Bass & Treble.
First appearance of Auto.