This show's theme song was sung by Sir Tom Jones, in a style reminiscent to his performance of the theme song from the James Bond movie Thunderball (1965). Jones also appeared in caricature form in season two, episode four, "Talent Show a Go-Go/The Love of a Father", to sing his signature song, "It's Not Unusual".
Though he was briefly referenced in two episodes, Bugs Bunny did not make an appearance on this show.
Many other familiar characters from the Looney Tunes pantheon were featured on this show, often given traits to fit within Duck Dodgers' own universe. For example: Yosemite Sam became "K'chutha Sa'am", a parody of Klingons on Star Trek: The Original Series (1966). Elmer Fudd became a parasitic mind-altering alien disease known as "The Fudd", though more closely resembling The Borg in Star Trek: The Next Generation (1987). Taz was a barbaric ship Captain forced into single combat with Dodgers (a parody of the Star Trek: The Original Series (1966) episode "Arena". Wile E. Coyote showed up as a Predator-like alien hunting the Martian Commander.
This is the first Looney Tunes franchise to be aired on Cartoon Network before Kids' WB! went defunct in 2008.
In season one, episode nine, "The Green Loontern", Dodgers temporarily becomes a Green Lantern (of DC Comics fame) after accidentally picking up the wrong laundry. Movie director Kevin Smith has a cameo as the voice of Hal Jordan, when he finally shows up to reclaim his Power Ring and Superhero Suit.