This is Nickelodeon's fourth crossover between two of its shows (the first three being Rugrats (1991)/Aaahh!!! Real Monsters (1994), Kenan & Kel (1996)/Cousin Skeeter (1998), and Rugrats (1991)/The Wild Thornberrys (1998)).
The two boy protagonists, Jimmy Neutron and Timmy Turner, are voiced by two women - Debi Derryberry and Tara Strong.
Debi Derryberry and Tara Strong later appeared in The Emoji Movie (2017) providing voice cameos.