Filming only took four weeks.
In real-life, the website that Dr. Bedlam mentions ("professorbedlam") linked directly to the official Fox movies website. The site has since lapsed.
The architecture office work space in the movie is the actual office of renowned architect Robert A.M. Stern in New York City.
Anna Faris recounted an incident in which director Ivan Reitman "slapped my ass" and "humiliated" her on the set of this film during an interview with Lena Dunham on Faris' Unqualified podcast in Oct. 2022. She said, "I was doing a scene where I was on a ladder and I was supposed to be taking books off a shelf and he slapped my ass in front of the crew so hard. And all I could do was giggle." Faris previously spoke about the experience in 2017 but did not name the director.