Cody Travers, the heroic Metro City street fighter of the classic Final Fight series, has been released from prison and has reunited with his younger brother Kyle, an ex-marine with a natural talent for fighting. The two barely make ends meet, surviving on cash earned from the underground fight club scenes. As Cody, Kyle's trainer and best friend, begins to miss his glory days as the star fighter, he begins working deals with local mob bosses to get his hands on a new drug that dramatically enhances his strength while destroying his mind as well. When the mysterious drug ring leader decides to kidnap Cody, Kyle embarks on a one-man mission to get his brother... and his hood.... back from evil.