"Otis, the Deputy" marks the last appearance of Hal Smith as Otis Campbell, Mayberry's genial town drunk.
Ford Motor Company supplied most automobiles for the series. However, Howard's car is a 1964 Chevrolet Biscayne.
Character actor Joe Turkel plays Fred, one of the bank robbers. With over 140 roles to his career he was cast mostly as conventional heavies until his role as the ghost bartender Lloyd in Stanley Kubrick's "The Shining," after which he reached a cult status.
Andy mentions the bank robbers could have cut off Route 88 just before Franklin Junction. It's a private road that connects with the main highway and it's not on the map. This is the first mention of these roadways in Mayberry.