In the cold opening, Sam argues with an umpire. Sam mentions three players: Thurman Munson (Catcher), Roy White (Outfielder), and Chris Chambliss (First baseman) were all actually on the 1975 New York Yankees. Incidentally, this also means that Sam played at least part of a season in which the Red Sox made it to the World Series as 1975 is the year Carlton Fisk famously hit a game winning home run to force a Game Seven that they eventually lost.
Using calculations based on Norm's statement, he take a sip of beer once every 82.75 seconds.
Frederick's first word, "gak" is actually in the dictionary. It refers to a sticky or messy substance.
The episode's title is a reference to the 1962 pop song, "Breaking Up is Hard to Do" by Neil Sedaka.
Norm says that with a cigar Frederick looks just like Baby Herman. This was a cartoon character in Who Framed Roger Rabbit (1988).