Ted Danson would later host Star Trek: 30 Years and Beyond (1996), which featured a sketch where Kate Mulgrew "reenacted" her Star Trek: Voyager (1995) audition with Frasier (1993) supporting cast members Peri Gilpin (who would later appear in Woody Gets an Election (1993)), John Mahoney (who would later appear in Do Not Forsake Me, O' My Postman (1992)), Jane Leeves and David Hyde Pierce as their characters.
The title refers to the common expression "Politics makes strange bedfellows" commenting on the odd compromises and partnerships that come in the political arena.
Kate Mulgrew "Janet Eldridge" went on to play "Red" in the Netflix hit "Orange is the New Black"