The scene where Cheryl asks Larry why she's the one who must initiate sex is from a real conversation Larry David had with his friend Michael E. Perry. Michael stated that guys are ready 24/7 and it's the job of the wife to initiate the action. Much like a car in a garage is ready to be driven at any moment but the owner must be willing to initiate the drive.
Cheryl and Larry end up in an actual Longs Drugs Store. A successful chain of Drug Stores started in Oakland, California in 1938 by the Longs brothers. The entire chain of 521 Longs Drugs stores was purchased by CVS in 2008. As of 2024, only the stores in Hawaii kept the Longs Drugs name.