Although this episode "The First Time" (Ep. #9.16), in which Natalie lost her virginity, was written initially for Blair. However, Lisa Whelchel refused to appear in this episode as it conflicted with her firmly held values. Whelchel, a practicing Christian, did not want to appear to condone sex before marriage. This was the only episode of the series in which Blair did not appear.
This episode is the first time Natalie and Tootie's attic bedroom was shown since being remodeled the season previously.
Per the common practice of altering brand names of products on-screen, during the breakfast scene, Jo pours herself a bowl of "ape nuts."