A gag was animated that involved "The Newlywed Game", featuring the biblical figures Mary and Joseph (the human parents of Jesus Christ). Bob Eubanks actually came in and did the voice of his character for the gag, but quickly pulled out after realizing the nature of the joke (he had just finished work on a "Christian Workout Video").
In the "Super Griffins," episode Mayor Adam West utters the line "I've tangled with super beings before." Adam West has played Batman in the television show and movie of Batman. His character frequently faces off with super beings such as the Family Guy character indicates.
Originally Season 3 Episode 12 released as Season 3 Episode 21.
After Mayor West rolls around in toxic waste to gain superpowers, Dr. Hartman tells him he has lymphoma. In real life, Adam West died of leukemia, another type of blood cancer.
Music from this episode is featured on the CD soundtrack album "Family Guy - Movement 1".