When Niles (David Hyde Pierce) is talking to Roz (Peri Gilpin) about Daphne's success at the 'spa,' he indicates that Daphne has already lost 9 pounds 12 ounces, which was the weight of Jane Leeves' newborn daughter, Isabella.
The title is taken from the expression "It takes two to tango."
This is the first appearance of barista/waiter James, played by James Oliver. He will have a continuing role in 11 more episodes as one of the more personable employees at Nervosa who gets mildly entangled in some of the cast's conversations and situations.