In real life, the actor who portrays Uncle Phil (James Avery) died due to complications related to heart surgery. On his death certificate it was confirmed that he suffered from severe coronary heart disease - along with end-stage kidney disease and type-2 diabetes. Avery's official cause of death is listed as cardiorespiratory arrest.
When Dr. Kevarkian introduces himself, everyone lets out a gasp because they think he said Dr. Kevorkian before correcting himself by saying "Kevarkian with an "a" a reference to Dr Jack Kevorkian who was arrested in 1998 for his involvement in assisted suicide.
The title is a play on the phrase "home is where the heart is"