At around 10 minutes, it shows Dr. Holland walking down the hospital hallway to the nurse's station. This is the same hallway used on Emergency! (1972) at "Rampart General Hospital".
"Pleasant Valley", at least part of it was Calabasas. As Mannix was driving into town the Chevron Calabasas Garage is seen.
Joe Mannix and Andrea (Laurel Goodwin) were supposed to have gone to college together. Mike Connors was 17 years older than her.
This episode has a number of actors and actresses that also had at least one guest star role in Star Trek (1966). Tom Troupe, Lee Meriwether, Laurel Goodwin, Logan Ramsey, and Barbara Babcock. Barbara Babcock had two on-screen roles, and four voice roles. In addition, Barbara Bosson had one guest star role on Star Trek: Deep Space Nine (1993).