This is the only episode of the series to feature its two most prolific guest stars, Alex Diakun (Mr. Wilkes / Father Claridge) and Eric Schneider (Dr. Miles Osgoode), who each appeared in eight episodes.
The title reference comes from the First Inaugural Address of Franklin D. Roosevelt on March 4, 1933: "So, first of all, let me assert my firm belief that the only thing we have to fear... is fear itself - nameless, unreasoning, unjustified terror..."
Although Bernard Selden is said to be 27 years old, Arye Gross was already 37 when this episode was made.