Claire Wilcox (Button Blake) and David Macklin (Mike Sommers) were on a TV series at the time called Harris Against the World (1964) with Jack Klugman. The series lasted only one season.
Nearly 20 years later, Julie Adams and Ed Nelson again played a married couple at odds when they were cast members of the CBS-TV soap opera, Capitol (1982). Adams played the deceitful agoraphobic, Paula Denning, and Nelson played her husband, Senator Mark Denning. Further connection to "Perry Mason" is that Senator Denning's long-time unrequited love was Clarissa McCandless, played by five-time Perry Mason guest cast member Constance Towers.
Perry Mason drives the classic "suicide door" 1964 Lincoln Continental with tag OPD 384.