After Roseanne's surgery in the episode, she's looking at herself in a mirror and verbally expresses that her belly is "next to go." This is a real-life foreshadow of Roseanne Barr's continuation of her cosmetic surgeries which included an actual breast reduction, nose job and tummy tuck.
In Roseanne's dream sequence, Neil Patrick Harris cameos as his character from "Doogie Howser, M.D."