The Sliders arrive on an Earth struck by a plague. Soon after landing, they discover that the local Quinn (Jerry O'Connell) is wanted by authorities for being the originator of the plague, and Wade (Sabrina Lloyd) accidentally catches it. Slider Quinn is captured by the California Health Commission, thinking he is their Quinn. The rest of the Sliders encounter the local Quinn, who has refugee-type shelters for the ill not wishing to surrender themselves to the tender mercies of the cruel CHC . Arturo teams with the Local Quinn to gather enough mold to be able to synthesize enough Penicillin to be effective. Testing it upon himself, he proves his goo cocktail to be a success, and hurriedly scrambles to create enough to give Local Quinn and his dying minions the cure in time to not only catch the next portal but evcade the CHC in their brutal scour.