Cartman's mom is named Liane after Trey Parker's former fiancée. He caught her with another man once, and he now names every immoral woman in the show after her.
Jesus is seen at the bar drinking beer out of the Holy Grail.
Days after the premiere, Bob Saget was interviewed on The Daily Show (1996) about his appearance. He said at first he felt offended when he saw his character but later on he got the joke.
Every time Ms. Cartman sees a guy at the Drunken Barn Dance, a love theme is played. This theme is a parody of the Céline Dion song "My Heart Will Go On" from Titanic (1997) with similar lyrics
The episode was to conclude with the first episode of the second season, on April 1 1998, four weeks after "Cartman's Mom is a Dirty Slut" was first broadcast. However, instead Trey Parker and Matt Stone made an episode about Terrance and Philip, as an April Fool's Day prank on viewers. Upset fans wrote more than 2000 angry e-mail complaints to Comedy Central within a week of the episode's original broadcast, and media outlets said some fans harbored a grudge against the show more than five years after the episode was broadcast. "Cartman's Mom Is Still a Dirty Slut", the second part of the episode, was originally set to air on May 20 1998, but due to the angry feedback Comedy Central moved up the airdate to April 22 1998.