This episode features the first full appearance of Venom.
The probe launch was named after Colonel John Jameson, which is fitting since the whole alien costume saga started in space on the space shuttle John Jameson piloted.
This episode is loosely based on "The Amazing Spider-Man" (Vol. 1) #300, the first full appearance of Venom in the comics.
According to Venom, the symbiote is a life-force that has existed since the dawn of time that has seen thousands of worlds, millions of civilizations, and learned many secrets, but always had one goal above all else... to survive.
When bonded with Eddie Brock, the symbiote features a mouth with sharp teeth and a long tongue. Also it now has red highlights in addition to the blue highlights.