Barbara Nichols accidentally fell when she was running down the airplane stairs and back on to the runway. Although Barbara's fall on the tarmac wasn't in the script, director Jack Smight loved it and kept this shot in.
Arlene Martel (credited here as Arlene Sax) plays the nurse in the morgue who taunts Liz Powell with the "room for one more," line. In order to make her look more sinister, they used makeup to give her a somewhat demonic look, complete with arched eyebrows. She would later land her most famous role, that of T'Pring, the woman betrothed to Spock in Amok Time (1967). The interesting thing is that a picture of her as the nurse in "Twenty-Two" is almost identical to her appearance in "Amok Time."
The fourth of six episodes to be videotaped.
The story was adapted by Rod Serling from a short anecdote in the 1944 Bennett Cerf Random House anthology Famous Ghost Stories, which itself was an adaptation of "The Bus-Conductor", a short story by E.F. Benson. "The Bus-Conductor" is also the inspiration for one of the segments in the anthology horror film Dead of Night (1945).
Wesley Lau, who played the airline agent at the ticket counter, played Lt. Anderson in 81 episodes of Perry Mason (1957).