At 16:59 as Ollie's wife is driving toward the accident site, the MGM Studio buildings are visible in the background. This location shot as well as the other street scenes are just a block from where the show was produced.
The house that was used as the exterior of the Pope's home still stands at 4183 Keystone Avenue in Culver City, CA. It is still very recognizable from the 1964 episode.
Oliver Pope's car is a 1956 Ford Fairlane Club Sedan.
The title refers to an old Hertz Car Rental ad campaign which called their cars "U Drives". Bud Abbott and Lou Costello turned the U-Drive theme into a famous comedy sketch similar to their "Who's on first?" sketch.
You Drive is one of two Twilight Zone episodes featuring a car driven without a driver. The other is A Thing About Machines (1960) from season 2.